Selective autophagy

Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Autophagy can be a selective process where specific cargo (organelles/proteins) are targetted to degradation in the lysosome. In general, selective autophagy is initiated when a cellular signal tags the cargo organelle for degradation. Subsequently, cargo recognition proteins detect and recruit the organelle to interact directly or indirectly with Atg proteins forming the phagophore. The next steps involve formation of the autophagosome and fusion with the lysosome for degradation. Depending upon the organelle, different molecules are used to for the autophagy mechanism (Andling AL et al. 2017). Consequently, the different mechanisms are known by the organelle degraded such as mitophagy for mitochondia and lipophagy for lipid droplets.

Literature References
PubMed ID Title Journal Year
28399394 Cleaning House: Selective Autophagy of Organelles

Anding, AL, Baehrecke, EH

Dev. Cell 2017
Participants
Participant Of
hasEvent
Event Information
Go Biological Process
Orthologous Events
Authored
Created
Cite Us!