Reactome | ATM binds PEX5

ATM binds PEX5

Stable Identifier

R-HSA-9664850

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SVG | | PPTX | SBGN

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The first step in pexophagy is the initiation by a signal that triggers downstream events to eventually degrade the peroxisome. Ataxia-telangiectasia mutated protein (ATM) is a serine/threonine protein kinase that is involve in DNA damage response. ATM is known to be involved in pexophagy (Katarzyna ZR et al. 2016). ATM binds with Peroxisomal targeting signal 1 receptor (PEX5) with the help of a SRL binding sequence in ATM (Zhang J et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
27068951	Autophagic degradation of peroxisomes in mammals Subramani, S, Zientara-Rytter, K	Biochem. Soc. Trans.	2016
26344566	ATM functions at the peroxisome to induce pexophagy in response to ROS Kim, J, Walker, CL, Pandita, TK, Charaka, VK, Jing, J, Dere, R, Zhang, J, Kastan, MB, Lee, JH, Alexander, A, Pandita, RK, Paull, TT, Tripathi, DN, Powell, RT, Tait-Mulder, J	Nat. Cell Biol.	2015