NBR1 binds ATM:Ub-p-PEX5:SQSTM1

Stable Identifier
R-HSA-9664881
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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As autophagy receptors, Next to BRCA1 gene 1 protein (NBR1) and Sequestosome 1 (SQSTM1) can cooperate to achieve pexophagy. SQSTM1 supports NBR1 to bind ubiquitinated peroxisomes through its UBA domain and enhances the efficiency of the degradation process (Kirkin V et al. 2009).

Literature References
PubMed ID Title Journal Year
19398892 NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets

Kirkin, V, Lamark, T, Johansen, T, Dikic, I

Autophagy 2009
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