SQSTM1 binds ATM dimer:Ub-p-PEX5

Stable Identifier
R-HSA-9664892
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Sequestosome 1 (SQSTM1) is an autophagy adaptor that serves to bridge ubiquitinated cargo and the autophagosome. It binds ubiquitinated cargo via its UBA domain. SQSTM1 in the cytosol recognizes and binds with ubiquitinated Peroxisomal targeting signal 1 receptor (PEX5) in the peroxisomal membrane (Zhang et al. 2015).

Literature References
PubMed ID Title Journal Year
26344566 ATM functions at the peroxisome to induce pexophagy in response to ROS

Zhang, J, Tripathi, DN, Jing, J, Alexander, A, Kim, J, Powell, RT, Dere, R, Tait-Mulder, J, Lee, JH, Paull, TT, Pandita, RK, Charaka, VK, Pandita, TK, Kastan, MB, Walker, CL

Nat. Cell Biol. 2015
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