ERBB2 S310F [plasma membrane]

Stable Identifier
R-HSA-9665350
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
ERBB2 Ser310Phe
ERBB2 S310F [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
22908275 Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2

Walker, SR, Greulich, H, Pho, NH, Banerji, S, Berger, AH, Lawrence, MS, Getz, G, Frank, D, Tanaka, KE, Chen, TH, Mani, DR, Liao, R, Imielinski, M, Winckler, W, Lee, SH, Meyerson, M, Hahn, WC, Wong, KK, Ambrogio, L, Kaplan, B, Cho, J, Mertins, P, Carr, SA, Jaffe, JD, Zhang, X, Eck, MJ, Yun, CH, Zhang, J

Proc. Natl. Acad. Sci. U.S.A. 2012
External Reference Information
External Reference
Gene Names
ERBB2, HER2, MLN19, NEU, NGL
Chain
signal peptide:1-22, chain:23-1255
Other Identifiers
11736472_a_at
11750611_a_at
11751416_a_at
11755005_a_at
11762165_x_at
16833839
1802_s_at
1901_s_at
2064
210930_3p_s_at
210930_PM_s_at
210930_s_at
216836_PM_s_at
216836_s_at
33218_at
3720403
3720404
3720405
3720406
3720407
3720408
3720410
3720411
3720412
3720413
3720417
3720420
3720422
3720423
3720425
3720427
3720428
3720431
3720432
3720433
3720434
3720436
3720438
3720440
3720442
3720444
3720446
3720447
3720449
3720452
3720454
3720455
3720457
3720458
3720460
3720461
3720462
3720463
3720464
3720465
3720466
3720467
3720468
3720469
3720470
3720471
8006906
A_14_P101724
A_14_P126019
A_23_P89249
A_24_P284420
A_33_P3292596
GE57810
GO:0000166
GO:0001042
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0004888
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006886
GO:0007155
GO:0007165
GO:0007166
GO:0007167
GO:0007169
GO:0007399
GO:0007422
GO:0007507
GO:0007528
GO:0008045
GO:0008284
GO:0009925
GO:0010008
GO:0010628
GO:0012501
GO:0014065
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0018108
GO:0019838
GO:0022008
GO:0023052
GO:0030154
GO:0030182
GO:0030307
GO:0031410
GO:0031594
GO:0032587
GO:0032886
GO:0033080
GO:0033088
GO:0033674
GO:0034330
GO:0035556
GO:0036211
GO:0038127
GO:0038133
GO:0038134
GO:0038135
GO:0038143
GO:0042060
GO:0042127
GO:0042552
GO:0042734
GO:0042802
GO:0042995
GO:0043066
GO:0043125
GO:0043209
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043547
GO:0045727
GO:0045765
GO:0045785
GO:0045943
GO:0046777
GO:0046982
GO:0048471
GO:0048709
GO:0048856
GO:0050679
GO:0050790
GO:0060089
GO:0070372
GO:0071363
GO:0071364
GO:0090314
GO:0098590
GO:0099645
GO:0140096
HMNXSV003015366
HMNXSV003026104
HMNXSV003035749
Hs.323910.2.A1_3p_a_at
ILMN_1717902
ILMN_1728761
ILMN_2352131
PH_hs_0021933
TC17000480.hg
X03363_s_at
g10181232_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
L-serine 310 replaced with L-phenylalanine
Coordinate
310
PsiMod
A protein modification that effectively converts a source amino acid residue to L-phenylalanine.
A protein modification that effectively removes or replaces an L-serine.
Disease
Name Identifier Synonyms
invasive bladder transitional cell carcinoma DOID:6477 Invasive bladder Urothelial carcinoma
pharynx cancer DOID:0060119
cervical adenocarcinoma DOID:3702 adenocarcinoma of cervix, adenocarcinoma cervix uteri, adenocarcinoma of the uterine Cervix
nasal cavity carcinoma DOID:4931 cancer of nasal cavity, carcinoma of nasal cavity
lung adenocarcinoma DOID:3910 nonsmall cell adenocarcinoma
stomach cancer DOID:10534 malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
bladder squamous cell carcinoma DOID:3742 Epidermoid carcinoma of the urinary bladder, squamous cell carcinoma of bladder
bladder adenocarcinoma DOID:3711 adenocarcinoma of bladder, bladder adenocarcinoma, Not Otherwise Specified, adenocarcinoma of the urinary bladder
bile duct carcinoma DOID:4897
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
gallbladder adenocarcinoma DOID:3500 adenocarcinoma of the gallbladder
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
cervical squamous cell carcinoma DOID:3744 squamous cell carcinoma of the Cervix Uteri, squamous cell carcinoma of cervix
rhabdomyosarcoma DOID:3247 Rhabdomyosarcoma NOS (morphologic abnormality), rhabdomyosarcoma, Rhabdomyosarcoma, no subtype (morphologic abnormality), rhabdomyoblastoma, Rhabdomyosarcoma (disorder)
ovarian cancer DOID:2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
skin melanoma DOID:8923 malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma
pancreatic cancer DOID:1793 malignant neoplasm of tail of pancreas, pancreatic tumor, Ca body of pancreas, pancreas neoplasm, malignant neoplasm of body of pancreas, pancreatic neoplasm, malignant tumor of body of pancreas (disorder), Ca tail of pancreas (disorder), malignant neoplasm of head of pancreas, Ca tail of pancreas, malignant tumor of tail of pancreas (disorder), neoplasm of pancreas (disorder), Ca head of pancreas, Ca body of pancreas (disorder)
basal cell carcinoma DOID:2513 malignant Basal cell neoplasm, malignant basal cell tumor, malignant basal cell tumor (morphologic abnormality), Basal cell cancer, BASAL CELL carcinoma OF SKIN, Rodent ulcer, Rodent ulcer, Basal cell carcinoma NOS (morphologic abnormality), Basal cell neoplasm NOS (morphologic abnormality), Rodent ulcer, basal cell carcinoma, Basal cell carcinoma (morphologic abnormality), Epithelioma basal cell (disorder), basal cell neoplasm, Basal cell neoplasm (morphologic abnormality), Basal cell tumor (morphologic abnormality), Rodent ulcer, Basal cell carcinoma of skin (disorder), Basal cell tumor
skin squamous cell carcinoma DOID:3151 Epidermoid skin carcinoma, squamous cell carcinoma of skin (disorder)
pancreatic ductal adenocarcinoma DOID:3498 ductal adenocarcinoma of the pancreas
salivary gland cancer DOID:8850 malignant neoplasm of salivary gland NOS, malignant tumor of the Salivary gland, malignant neoplasm of salivary gland duct, malignant neoplasm of major salivary gland, NOS, malignant neoplasm of major salivary gland NOS (disorder), malignant neoplasm of major salivary gland NOS, malignant neoplasm of salivary gland, malignant neoplasm of salivary gland, unspecified, malignant tumor of salivary gland (disorder), malignant tumor of major salivary gland (disorder), malignant tumor of the Major Salivary gland, malignant neoplasm of major salivary gland, malignant neoplasm of other major salivary glands (disorder), malignant neoplasm of other major salivary glands
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Investigational
ZINC - Metabolites
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (72)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P21860 ERBB3      0.973 30
 UniProt:P00533 EGFR  20 0.954 25
 UniProt:P04626 ERBB2  20 0.926 12
 UniProt:P62993 GRB2  1 0.916 8
 UniProt:P07900 HSP90AA1  8 0.856 6
 UniProt:P29353 SHC1  5 0.821 16
 UniProt:Q15303 ERBB4      0.816 5
 UniProt:P08238 HSP90AB1  6 0.793 5
 UniProt:Q14451 GRB7  1 0.779 5
 UniProt:P40763 STAT3  12 0.775 9
 UniProt:P27986 PIK3R1  16 0.759 12
 UniProt:Q96JA1 LRIG1  2 0.748 7
 UniProt:P12931 SRC  6 0.708 11
 UniProt:O00459 PIK3R2  2 0.702 8
 UniProt:Q16543 CDC37  1 0.695 5
 UniProt:O95292 VAPB  2 0.671 4
 UniProt:P02786 TFRC  5 0.671 4
 UniProt:Q9UJM3 ERRFI      0.659 4
 UniProt:P11021 HSPA5  6 0.659 3
 UniProt:P05023 ATP1A1  1 0.643 3
 UniProt:P0DTD8 NS7B      0.643 3
 UniProt:Q13882 PTK6  5 0.628 4
 UniProt:P46940 IQGAP1  3 0.602 5
 IntAct:EBI-11820565 HSPA1A      0.594 3
 UniProt:Q9UQF2 JIP1      0.592 4
 UniProt:Q06124 PTPN11  4 0.592 3
 UniProt:Q05209 PTPN12  2 0.592 4
 UniProt:P20936 RASA1  1 0.592 8
 UniProt:Q92569 PIK3R3  2 0.59 10
 UniProt:P42679 MATK  1 0.59 2
 IntAct:EBI-4399559 UBIQ      0.589 2
 UniProt:Q9HB71 CYBP      0.573 2
 UniProt:P31948 STIP1  1 0.573 2
 UniProt:O75791 GRAP2  1 0.571 2
 UniProt:P16885 PLCG2  8 0.571 3
 UniProt:P42224 STAT1  8 0.571 3
 UniProt:O60884 DNAJA2  1 0.569 3
 UniProt:P27824 CANX  2 0.569 3
 UniProt:Q15075 EEA1  1 0.567 5
 UniProt:Q14974 KPNB1  5 0.567 14
 UniProt:O95602 POLR1A  1 0.567 16
 UniProt:O14980 XPO1  2 0.564 3
 UniProt:Q99952 PTPN18  2 0.558 6
 UniProt:P06241 FYN  6 0.558 2
 UniProt:O95980 RECK  2 0.556 4
 UniProt:O75367 H2AY      0.556 6
 UniProt:Q9P2T1 GMPR2  1 0.553 2
 UniProt:Q9UBN7 HDAC6  4 0.553 2
 UniProt:P04406 GAPDH  1 0.553 2
 UniProt:Q9P0L0 VAPA  4 0.547 2
 UniProt:Q14318 FKBP8  2 0.547 2
 UniProt:P60709 ACTB  5 0.537 10
 UniProt:Q05397 PTK2  11 0.536 2
 UniProt:P31689 DNAJA1  1 0.527 2
 UniProt:P61619 SEC61A1  2 0.527 2
 UniProt:P36542 ATP5F1C  1 0.527 2
 UniProt:O00483 NDUFA4  1 0.527 2
 UniProt:O95573 ACSL3  2 0.527 2
 UniProt:Q8WUY1 THEM6      0.527 2
 UniProt:Q9NVI7 ATD3A      0.527 2
 UniProt:P42704 LRPPRC  1 0.527 2
 UniProt:Q00325 S25A3      0.527 2
 UniProt:Q9BVV7 TIMM21  1 0.527 2
 UniProt:Q3ZCQ8 TIMM50  1 0.527 2
 UniProt:Q92504 SLC39A7  1 0.527 2
 UniProt:O00750 PIK3C2B  1 0.525 2
 UniProt:Q99952-1 PTPN18      0.524 5
 IntAct:EBI-5590949 HAS      0.524 2
 UniProt:Q15256 PTPRR      0.508 2
 UniProt:P15309 ACP3  2 0.472 2
 UniProt:P98172 EFNB1  2 0.463 11
 UniProt:P49792 RANBP2  6 0.463 3
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