Reactome | ERBB2 R678Q [plasma membrane]

ERBB2 R678Q [plasma membrane]

Stable Identifier

R-HSA-9665756

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
30449325	Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations Pahuja, KB, Nguyen, TT, Jaiswal, BS, Prabhash, K, Thaker, TM, Senger, K, Chaudhuri, S, Kljavin, NM, Antony, A, Phalke, S, Kumar, P, Mravic, M, Stawiski, EW, Vargas, D, Durinck, S, Gupta, R, Khanna-Gupta, A, Trabucco, SE, Sokol, ES, Hartmaier, RJ, Singh, A, Chougule, A, Trivedi, V, Dutt, A, Patil, V, Joshi, A, Noronha, V, Ziai, J, Banavali, SD, Ramprasad, V, DeGrado, WF, Bueno, R, Jura, N, Seshagiri, S	Cancer Cell	2018
24971884	Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib de Martino, M, Zhuang, D, Klatte, T, Rieken, M, Rouprêt, M, Xylinas, E, Clozel, T, Krzywinski, M, Elemento, O, Shariat, SF	Cancer Biol. Ther.	2014
23220880	Activating HER2 mutations in HER2 gene amplification negative breast cancer Bose, R, Kavuri, SM, Searleman, AC, Shen, W, Shen, D, Koboldt, DC, Monsey, J, Goel, N, Aronson, AB, Li, S, Ma, CX, Ding, L, Mardis, ER, Ellis, MJ	Cancer Discov	2013

External Reference Information

External Reference

UniProt:P04626 ERBB2

Gene Names

ERBB2, HER2, MLN19, NEU, NGL

Chain

signal peptide:1-22, chain:23-1255

Reference Genes

BioGPS Gene:2064 ERBB2

COSMIC (genes):ERBB2 ERBB2

CTD Gene:2064 ERBB2

dbSNP Gene:2064 ERBB2

ENSEMBL:ENSG00000141736 ERBB2

HGNC:3430 ERBB2

KEGG Gene (Homo sapiens):2064 ERBB2

Monarch:2064 ERBB2

NCBI Gene:2064 ERBB2

OMIM:164870 ERBB2

UCSC:P04626 ERBB2

Reference Transcript

Other Identifiers

0106040504

11736472_a_at

11750611_a_at

11751416_a_at

11755005_a_at

11762165_x_at

16833839

1802_s_at

1901_s_at

2064

210930_3p_s_at

210930_s_at

216836_s_at

33218_at

3720403

3720404

3720405

3720406

3720407

3720408

3720410

3720411

3720412

3720413

3720417

3720420

3720422

3720423

3720425

3720427

3720428

3720431

3720432

3720433

3720434

3720436

3720438

3720440

3720442

3720444

3720446

3720447

3720449

3720452

3720454

3720455

3720457

3720458

3720460

3720461

3720462

3720463

3720464

3720465

3720466

3720467

3720468

3720469

3720470

3720471

8006906

A_14_P101724

A_14_P126019

A_23_P89249

A_24_P284420

A_33_P3292596

GE57810

GO:0000165

GO:0000166

GO:0000902

GO:0001042

GO:0001934

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0004888

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0005887

GO:0006357

GO:0006412

GO:0006464

GO:0006468

GO:0006605

GO:0006810

GO:0006950

GO:0007155

GO:0007165

GO:0007166

GO:0007167

GO:0007169

GO:0007275

GO:0007399

GO:0007422

GO:0007507

GO:0007528

GO:0008022

GO:0008045

GO:0008150

GO:0008283

GO:0008284

GO:0009058

GO:0009925

GO:0010008

GO:0010628

GO:0014065

GO:0015031

GO:0016020

GO:0016021

GO:0016301

GO:0016310

GO:0016323

GO:0016324

GO:0016740

GO:0018108

GO:0019838

GO:0019899

GO:0019903

GO:0030154

GO:0030182

GO:0030307

GO:0031410

GO:0032886

GO:0032991

GO:0033088

GO:0033674

GO:0034330

GO:0034641

GO:0035556

GO:0038128

GO:0038143

GO:0040007

GO:0040011

GO:0042060

GO:0042552

GO:0042802

GO:0043125

GO:0043167

GO:0043209

GO:0043226

GO:0043235

GO:0043406

GO:0043410

GO:0043547

GO:0045727

GO:0045765

GO:0045785

GO:0045943

GO:0046777

GO:0046982

GO:0048471

GO:0048646

GO:0048709

GO:0048856

GO:0048870

GO:0050679

GO:0051897

GO:0070372

GO:0071363

GO:0071364

GO:0090314

GO:1901185

GO:2000145

Hs.323910.2.A1_3p_a_at

ILMN_1694303

ILMN_1717902

ILMN_1728761

ILMN_2352131

ILMN_3268199

PH_hs_0021933

TC17000480.hg

X03363_s_at

g10181232_3p_a_at

Participant Of

hasMember

hasComponent

Other forms of this molecule

ERBB2 G309E [plasma membrane]

ERBB2 G309A [plasma membrane]

ERBB2 S310F [plasma membrane]

ERBB2 S310Y [plasma membrane]

p-6Y-ERBB2 G309A [plasma membrane]

p-6Y-ERBB2 G309E [plasma membrane]

p-6Y-ERBB2 S310F [plasma membrane]

p-6Y-ERBB2 S310Y [plasma membrane]

p-Y-ERBB2 L755P [plasma membrane]

p-Y-ERBB2 I767M [plasma membrane]

p-Y-ERBB2 A775_G776insYVMA [plasma membrane]

p-Y-ERBB2 T798I [plasma membrane]

p-Y-ERBB2 T862A [plasma membrane]

p-Y-ERBB2 T798M [plasma membrane]

p-Y-ERBB2 H878Y [plasma membrane]

p-Y-ERBB2 V777L [plasma membrane]

p-Y-ERBB2 L755S [plasma membrane]

p-Y-ERBB2 V777E [plasma membrane]

p-Y-ERBB2 V777M [plasma membrane]

p-Y-ERBB2 L755M [plasma membrane]

p-Y-ERBB2 A771_Y772insYVMA [plasma membrane]

p-Y-ERBB2 L755W [plasma membrane]

p-Y-ERBB2 T733I [plasma membrane]

p-Y-ERBB2 H878R [plasma membrane]

p-Y-ERBB2 L869R [plasma membrane]

p-Y-ERBB2 G776S [plasma membrane]

p-Y-ERBB2 L869Q [plasma membrane]

p-Y-ERBB2 G776L [plasma membrane]

p-Y-ERBB2 G776V [plasma membrane]

p-Y-ERBB2 G776C [plasma membrane]

ERBB2 D769Y [plasma membrane]

ERBB2 L755P [plasma membrane]

ERBB2 V842I [plasma membrane]

ERBB2 H878Y [plasma membrane]

ERBB2 T798M [plasma membrane]

ERBB2 D769H [plasma membrane]

ERBB2 T862A [plasma membrane]

ERBB2 A775_G776insYVMA [plasma membrane]

ERBB2 L755S [plasma membrane]

ERBB2 I767M [plasma membrane]

ERBB2 V777L [plasma membrane]

ERBB2 D769N [plasma membrane]

ERBB2 T733I [plasma membrane]

ERBB2 V777M [plasma membrane]

ERBB2 V777E [plasma membrane]

ERBB2 L755W [plasma membrane]

ERBB2 L755M [plasma membrane]

ERBB2 A771_Y772insYVMA [plasma membrane]

ERBB2 H878R [plasma membrane]

ERBB2 V842E [plasma membrane]

ERBB2 T798I [plasma membrane]

ERBB2 R896C [plasma membrane]

ERBB2 P780_Y781insGSP [plasma membrane]

ERBB2 R896H [plasma membrane]

ERBB2 G778_P780insGSP [plasma membrane]

ERBB2 G776S [plasma membrane]

ERBB2 L869R [plasma membrane]

ERBB2 L869Q [plasma membrane]

ERBB2 G776C [plasma membrane]

ERBB2 G776L [plasma membrane]

ERBB2 G776V [plasma membrane]

p-6Y-ERBB2 V777L [plasma membrane]

p-6Y-ERBB2 H878Y [plasma membrane]

ERBB2 L755_T759del [plasma membrane]

p-6Y-ERBB2 R896C [plasma membrane]

p-6Y-ERBB2 V842I [plasma membrane]

p-6Y-ERBB2 I767M [plasma membrane]

p-6Y-ERBB2 T862A [plasma membrane]

p-6Y-ERBB2 D769H [plasma membrane]

p-6Y-ERBB2 T798I [plasma membrane]

p-6Y-ERBB2 L755P [plasma membrane]

p-6Y-ERBB2 P780_Y781insGSP [plasma membrane]

p-6Y-ERBB2 L755S [plasma membrane]

p-6Y-ERBB2 A775_G776insYVMA [plasma membrane]

p-6Y-ERBB2 T798M [plasma membrane]

p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane]

p-6Y-ERBB2 D769Y [plasma membrane]

p-6Y-ERBB2 V777E [plasma membrane]

p-6Y-ERBB2 T733I [plasma membrane]

p-6Y-ERBB2 L755M [plasma membrane]

p-6Y-ERBB2 V777M [plasma membrane]

p-6Y-ERBB2 V842E [plasma membrane]

p-6Y-ERBB2 D769N [plasma membrane]

p-6Y-ERBB2 R896H [plasma membrane]

p-6Y-ERBB2 L755W [plasma membrane]

p-6Y-ERBB2 G778_P780insGSP [plasma membrane]

p-6Y-ERBB2 H878R [plasma membrane]

p-6Y-ERBB2 E693K [plasma membrane]

p-6Y-ERBB2 R677L [plasma membrane]

p-6Y-ERBB2 Q709L [plasma membrane]

p-6Y-ERBB2 G660D [plasma membrane]

p-6Y-ERBB2 G660R [plasma membrane]

p-6Y-ERBB2 V659K [plasma membrane]

p-6Y-ERBB2 V659E [plasma membrane]

ERBB2 S653C [plasma membrane]

ERBB2 R677L [plasma membrane]

ERBB2 G660R [plasma membrane]

ERBB2 V659E [plasma membrane]

ERBB2 G660D [plasma membrane]

ERBB2 V659K [plasma membrane]

ERBB2 Q709L [plasma membrane]

ERBB2 E693K [plasma membrane]

p-6Y-ERBB2 R678Q [plasma membrane]

p-6Y-ERBB2 S653C [plasma membrane]

p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877-ERBB2 [plasma membrane]

ERBB2 [plasma membrane]

p-6Y-ERBB2 [plasma membrane]

p-6Y,Y1112-ERBB2 [plasma membrane]

p-Y-ERBB2 [plasma membrane]

p-Y,Y877-ERBB2 [plasma membrane]

p-7Y,Y1112-ERBB2 [plasma membrane]

p-7Y-ERBB2 [plasma membrane]

Modified Residues

Name

L-arginine 678 replaced with L-glutamine

Coordinate

678

PsiMod

L-glutamine residue [MOD:00016]

A protein modification that effectively converts a source amino acid residue to an L-glutamine.

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

Disease

Name	Identifier	Synonyms
esophagus squamous cell carcinoma	3748	SCC of esophagus, squamous cell carcinoma of esophagus
pharynx cancer	0060119
stomach cancer	10534	malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
nasopharynx carcinoma	9261	malignant neoplasm of nasopharynx, malignant neoplasm of anterior wall of nasopharynx, malignant neoplasm of lateral wall of nasopharynx, malignant tumor of lateral wall of nasopharynx, Nasopharyngeal carcinoma, carcinoma of nasopharynx, malignant tumor of posterior wall of nasopharynx, malignant Nasopharyngeal tumor, malignant neoplasm of posterior wall of nasopharynx, malignant neoplasm of nasopharyngeal wall, malignant neoplasm of other specified sites of nasopharynx, primary malignant neoplasm of anterior wall of nasopharynx, malignant tumor of anterior wall of nasopharynx, malignant neoplasm of roof of nasopharynx, malignant neoplasm of superior wall of nasopharynx, nasopharynx cancer
breast cancer	1612	malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
bile duct carcinoma	4897
small intestine carcinoma	4907	small intestinal carcinoma
large intestine cancer	5672	malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
gallbladder adenocarcinoma	3500	adenocarcinoma of the gallbladder
endometrial cancer	1380	primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
bladder carcinoma	4007	carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
rhabdomyosarcoma	3247	Rhabdomyosarcoma NOS (morphologic abnormality), rhabdomyosarcoma, Rhabdomyosarcoma, no subtype (morphologic abnormality), rhabdomyoblastoma, Rhabdomyosarcoma (disorder)
cervical cancer	4362	neoplasm of uterine cervix (disorder), tumor of the Cervix Uteri, cervix uteri cancer, cervical neoplasm, cervix cancer
cancer	162	malignant tumor, malignant neoplasm, primary cancer
pancreatic ductal adenocarcinoma	3498	ductal adenocarcinoma of the pancreas
esophagus adenocarcinoma	4914	Oesophageal adenocarcinoma, adenocarcinoma of esophagus

Cross References

RefSeq

NP_001005862.1, NP_004439.2, NP_001276865.1, NP_001276867.1

ZINC - World Drugs

ERBB2_HUMAN

OpenTargets

ENSG00000141736

ZINC - FDA approved

ERBB2_HUMAN

ZINC - Substances

ERBB2_HUMAN

ZINC target

P04626

ZINC - Biogenic

ERBB2_HUMAN

PRO

P04626

PDB

1QR1, 5O4G, 1MFG, 3PP0, 3WLW, 3BE1, 1N8Z, 3RCD, 6BGT, 6J71, 3MZW, 4HRL, 3N85, 3WSQ, 6ATT, 6OGE, 5MY6, 2JWA, 4HRM, 5TQS, 4GFU, 2A91, 4HRN, 2KS1, 2N2A, 5KWG, 5OB4, 2L4K, 1S78, 3H3B, 1OVC, 1MW4, 5K33, 1MFL

ZINC - Investigational

ERBB2_HUMAN

ZINC - Metabolites

ERBB2_HUMAN

COSMIC

COSM436498, COSM6907329

HPA

ENSG00000141736-ERBB2

GeneCards

P04626

Ensembl

ENSP00000269571, ENSP00000385185, ENST00000269571, ENSP00000462438, ENST00000406381, ENSP00000446466, ENSG00000141736, ENST00000541774, ENST00000584601

ZINC - Predictions - Purchasable

ERBB2_HUMAN

HMDB Protein

HMDBP01473

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21860 ERBB3			0.974	29
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.96	25
UniProt:P04626 ERBB2	117	ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-6Y-ERBB2 E693K [plasma membrane] (R-HSA-9665871) p-6Y-ERBB2 R677L [plasma membrane] (R-HSA-9665864) p-6Y-ERBB2 Q709L [plasma membrane] (R-HSA-9665865) p-6Y-ERBB2 G660D [plasma membrane] (R-HSA-9665866) p-6Y-ERBB2 G660R [plasma membrane] (R-HSA-9665878) p-6Y-ERBB2 V659K [plasma membrane] (R-HSA-9665863) p-6Y-ERBB2 V659E [plasma membrane] (R-HSA-9665874) ERBB2 R678Q [plasma membrane] (R-HSA-9665756) ERBB2 S653C [plasma membrane] (R-HSA-9665754) ERBB2 R677L [plasma membrane] (R-HSA-9665759) ERBB2 G660R [plasma membrane] (R-HSA-9665768) ERBB2 V659E [plasma membrane] (R-HSA-9665752) ERBB2 G660D [plasma membrane] (R-HSA-9665753) ERBB2 V659K [plasma membrane] (R-HSA-9665769) ERBB2 Q709L [plasma membrane] (R-HSA-9665770) ERBB2 E693K [plasma membrane] (R-HSA-9665761) p-6Y-ERBB2 R678Q [plasma membrane] (R-HSA-9665876) p-6Y-ERBB2 S653C [plasma membrane] (R-HSA-9665875) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.938	12
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.873	6
UniProt:P07900 HSP90AA1	8	HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.825	5
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.779	5
UniProt:Q15303 ERBB4			0.778	4
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.775	9
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.772	15
UniProt:Q96JA1 LRIG1	2	LRIG1 [plasma membrane] (R-HSA-197745) Ub-LRIG1 [plasma membrane] (R-HSA-8875434)	0.748	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.734	4
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.708	11
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.688	11
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) PTK6 [cytosol] (R-HSA-8848000) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.656	4
UniProt:O00459 PIK3R2	2	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554)	0.609	7
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.609	2
UniProt:P16885 PLCG2	10	PLCG2 [cytosol] (R-HSA-984806) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) PLCG2 [plasma membrane] (R-HSA-2023875) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) PLCG2 [cytosol] (R-HSA-1604645) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.609	3
UniProt:P42224 STAT1	7	p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624)	0.609	3
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.602	5
UniProt:Q9UQF2 JIP1			0.592	4
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.592	8
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.592	3
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.592	4
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.59	2
IntAct:EBI-4399559 UBIQ			0.589	2
UniProt:Q05397 PTK2	11	p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.589	2
UniProt:Q9HB71 CYBP			0.573	2
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.573	2
UniProt:Q15075 EEA1	1	EEA1 [endosome membrane] (R-HSA-187893)	0.567	5
UniProt:Q14974 KPNB1	5	KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.567	14
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.567	16
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.564	3
UniProt:P06241 FYN	6	MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410)	0.558	2
UniProt:Q99952 PTPN18	2	PTPN18 [cytosol] (R-HSA-8864101) PTPN18 [nucleoplasm] (R-HSA-9008900)	0.558	6
UniProt:O95980 RECK	2	GPI-RECK [plasma membrane] (R-HSA-8940687) cleaved GPI-RECK [extracellular region] (R-HSA-8941046)	0.556	4
UniProt:O75367 H2AY			0.556	6
UniProt:Q9P2T1 GMPR2	1	GMPR2 [cytosol] (R-HSA-514631)	0.553	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.553	2
UniProt:Q9UBN7 HDAC6	5	HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [cytosol] (R-HSA-9646404) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.553	2
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920) VAPA [plasma membrane] (R-HSA-6806269) VAPA [azurophil granule membrane] (R-HSA-6799364)	0.547	2
UniProt:Q9UJM3 ERRFI			0.547	3
UniProt:P11021 HSPA5	6	HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.547	2
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.537	10
UniProt:O95292 VAPB	1	VAPB [endoplasmic reticulum membrane] (R-HSA-429718)	0.527	2
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.527	2
UniProt:P02786 TFRC	5	TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829)	0.527	2
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.525	2
UniProt:Q99952-1 PTPN18			0.524	5
IntAct:EBI-5590949 HAS			0.524	2
UniProt:Q15256 PTPRR			0.508	2
UniProt:P15309 ACP3	2	ACPP [azurophil granule membrane] (R-HSA-6799214) ACPP [plasma membrane] (R-HSA-3229238)	0.472	2
UniProt:P98172 EFNB1	2	EFNB1 [plasma membrane] (R-HSA-2682327) p-Y324,Y329,Y343-EFNB1 [plasma membrane] (R-HSA-3928412)	0.463	11
UniProt:P49792 RANBP2	4	SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) SUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) RANBP2 [cytosol] (R-HSA-157703) RANBP2 [nuclear envelope] (R-HSA-2993756)	0.463	3

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