ERBB2 V659K [plasma membrane]

Stable Identifier
R-HSA-9665769
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ERBB2 V659K [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
30449325 Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations

Pahuja, KB, Nguyen, TT, Jaiswal, BS, Prabhash, K, Thaker, TM, Senger, K, Chaudhuri, S, Kljavin, NM, Antony, A, Phalke, S, Kumar, P, Mravic, M, Stawiski, EW, Vargas, D, Durinck, S, Gupta, R, Khanna-Gupta, A, Trabucco, SE, Sokol, ES, Hartmaier, RJ, Singh, A, Chougule, A, Trivedi, V, Dutt, A, Patil, V, Joshi, A, Noronha, V, Ziai, J, Banavali, SD, Ramprasad, V, DeGrado, WF, Bueno, R, Jura, N, Seshagiri, S

Cancer Cell 2018
External Reference Information
External Reference
Gene Names
ERBB2, HER2, MLN19, NEU, NGL
Chain
signal peptide:1-22, chain:23-1255
Other Identifiers
0106040504
11736472_a_at
11750611_a_at
11751416_a_at
11755005_a_at
11762165_x_at
16833839
1802_s_at
1901_s_at
2064
210930_3p_s_at
210930_s_at
216836_s_at
33218_at
3720403
3720404
3720405
3720406
3720407
3720408
3720410
3720411
3720412
3720413
3720417
3720420
3720422
3720423
3720425
3720427
3720428
3720431
3720432
3720433
3720434
3720436
3720438
3720440
3720442
3720444
3720446
3720447
3720449
3720452
3720454
3720455
3720457
3720458
3720460
3720461
3720462
3720463
3720464
3720465
3720466
3720467
3720468
3720469
3720470
3720471
8006906
A_14_P101724
A_14_P126019
A_23_P89249
A_24_P284420
A_33_P3292596
GE57810
GO:0000165
GO:0000166
GO:0000902
GO:0001042
GO:0001934
GO:0002376
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0004888
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0005887
GO:0006357
GO:0006412
GO:0006464
GO:0006468
GO:0006605
GO:0006810
GO:0006950
GO:0007155
GO:0007165
GO:0007166
GO:0007167
GO:0007169
GO:0007275
GO:0007399
GO:0007422
GO:0007507
GO:0007528
GO:0008022
GO:0008045
GO:0008150
GO:0008283
GO:0008284
GO:0009058
GO:0009925
GO:0010008
GO:0010628
GO:0014065
GO:0015031
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0018108
GO:0019838
GO:0019899
GO:0019903
GO:0030154
GO:0030182
GO:0030307
GO:0031410
GO:0032886
GO:0032991
GO:0033088
GO:0033674
GO:0034330
GO:0034641
GO:0035556
GO:0038128
GO:0038143
GO:0040007
GO:0040011
GO:0042060
GO:0042552
GO:0042802
GO:0043125
GO:0043167
GO:0043209
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043547
GO:0045727
GO:0045765
GO:0045785
GO:0045943
GO:0046777
GO:0046982
GO:0048471
GO:0048646
GO:0048709
GO:0048856
GO:0048870
GO:0050679
GO:0051897
GO:0070372
GO:0071363
GO:0071364
GO:0090314
GO:1901185
GO:2000145
Hs.323910.2.A1_3p_a_at
ILMN_1694303
ILMN_1717902
ILMN_1728761
ILMN_2352131
ILMN_3268199
PH_hs_0021933
TC17000480.hg
X03363_s_at
g10181232_3p_a_at
Participant Of
Other forms of this molecule
Modified Residues
Name
L-valine 659 replaced with L-glutamic acid
Coordinate
659
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
A protein modification that effectively removes or replaces an L-valine.
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Investigational
ZINC - Metabolites
GeneCards
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (53)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P21860 ERBB3      0.974 29
 UniProt:P00533 EGFR  59 0.96 25
 UniProt:P04626 ERBB2  117 0.938 12
 UniProt:P62993 GRB2  1 0.873 6
 UniProt:P07900 HSP90AA1  8 0.825 5
 UniProt:Q14451 GRB7  1 0.779 5
 UniProt:Q15303 ERBB4      0.778 4
 UniProt:P40763 STAT3  10 0.775 9
 UniProt:P29353 SHC1  5 0.772 15
 UniProt:Q96JA1 LRIG1  2 0.748 7
 UniProt:P08238 HSP90AB1  6 0.734 4
 UniProt:P12931 SRC  6 0.708 11
 UniProt:P27986 PIK3R1  15 0.688 11
 UniProt:Q13882 PTK6  5 0.656 4
 UniProt:P16885 PLCG2  10 0.609 3
 UniProt:O00459 PIK3R2  2 0.609 7
 UniProt:P42224 STAT1  7 0.609 3
 UniProt:O75791 GRAP2  1 0.609 2
 UniProt:P46940 IQGAP1  3 0.602 5
 UniProt:Q9UQF2 JIP1      0.592 4
 UniProt:P20936 RASA1  1 0.592 8
 UniProt:Q05209 PTPN12  2 0.592 4
 UniProt:Q06124 PTPN11  4 0.592 3
 UniProt:P42679 MATK  1 0.59 2
 IntAct:EBI-4399559 UBIQ      0.589 2
 UniProt:Q05397 PTK2  11 0.589 2
 UniProt:Q9HB71 CYBP      0.573 2
 UniProt:P31948 STIP1  1 0.573 2
 UniProt:O95602 POLR1A  1 0.567 16
 UniProt:Q15075 EEA1  1 0.567 5
 UniProt:Q14974 KPNB1  5 0.567 14
 UniProt:Q16543 CDC37  1 0.564 3
 UniProt:P06241 FYN  6 0.558 2
 UniProt:Q99952 PTPN18  2 0.558 6
 UniProt:O95980 RECK  2 0.556 4
 UniProt:O75367 H2AY      0.556 6
 UniProt:Q9P2T1 GMPR2  1 0.553 2
 UniProt:Q9UBN7 HDAC6  5 0.553 2
 UniProt:P04406 GAPDH  1 0.553 2
 UniProt:Q9P0L0 VAPA  4 0.547 2
 UniProt:P11021 HSPA5  6 0.547 2
 UniProt:Q9UJM3 ERRFI      0.547 3
 UniProt:P60709 ACTB  5 0.537 10
 UniProt:O95292 VAPB  1 0.527 2
 UniProt:P05023 ATP1A1  1 0.527 2
 UniProt:P02786 TFRC  5 0.527 2
 UniProt:O00750 PIK3C2B  1 0.525 2
 UniProt:Q99952-1 PTPN18      0.524 5
 IntAct:EBI-5590949 HAS      0.524 2
 UniProt:Q15256 PTPRR      0.508 2
 UniProt:P15309 ACP3  2 0.472 2
 UniProt:P98172 EFNB1  2 0.463 11
 UniProt:P49792 RANBP2  4 0.463 3
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