Reactome | APC E1306* [cytosol]

APC E1306* [cytosol]

Stable Identifier

R-HSA-9666975

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

APC E1306TER, Adenomatous polyposis coli protein, APC_HUMAN

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by WNT in cancer (Homo sapiens)
    - Signaling by APC mutants (Homo sapiens)
      - APC truncation mutants have impaired AXIN binding (Homo sapiens)
        
        APC truncation mutants have impaired AXIN binding (Homo sapiens)
        
        APC truncation mutants [cytosol] (Homo sapiens)
        
        APC E1306* [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25054 APC

Gene Names

APC, DP2.5

Chain

initiator methionine:, chain:2-2843

Reference Genes

COSMIC (genes):APC APC

dbSNP Gene:324 APC

ENSEMBL:ENSG00000134982 APC

Participates

as a candidate of

APC truncation mutants [cytosol] (Homo sapiens)

Other forms of this molecule

APC R213* [cytosol]

APC C1410* [cytosol]

APC K1310* [cytosol]

APC R499* [cytosol]

APC R1450* [cytosol]

APC G1357* [cytosol]

APC L1488* [cytosol]

APC S1400* [cytosol]

APC S1346* [cytosol]

APC R405* [cytosol]

APC S1281* [cytosol]

APC E1573* [cytosol]

APC R805* [cytosol]

APC R1386* [cytosol]

APC S1327* [cytosol]

APC E1209* [cytosol]

APC Q1469* [cytosol]

APC R564* [cytosol]

APC E1536* [cytosol]

APC G1288* [cytosol]

APC G1312* [cytosol]

APC R283* [cytosol]

APC Q1367* [cytosol]

APC E1353* [cytosol]

APC R332* [cytosol]

APC K993* [cytosol]

APC R876* [cytosol]

APC R302* [cytosol]

APC E1309* [cytosol]

APC Y935* [cytosol]

APC E1286* [cytosol]

APC Q1378* [cytosol]

APC R554* [cytosol]

APC S1356* [cytosol]

APC R232* [cytosol]

APC E1379* [cytosol]

APC E984* [cytosol]

APC R1114* [cytosol]

APC S1282* [cytosol]

APC Q1328* [cytosol]

APC E1295* [cytosol]

APC E1151* [cytosol]

APC E1322* [cytosol]

APC E1345* [cytosol]

APC K1308* [cytosol]

APC S1344* [cytosol]

APC E1577* [cytosol]

APC Q1127* [cytosol]

APC E1464* [cytosol]

APC E1317* [cytosol]

APC G1309Dfs*4 [cytosol]

APC W1049* [cytosol]

APC Q1429* [cytosol]

APC L1564* [cytosol]

APC Q1294* [cytosol]

APC K1363* [cytosol]

APC E1408* [cytosol]

APC E1284* [cytosol]

APC E1374* [cytosol]

APC Q767* [cytosol]

APC E941* [cytosol]

APC Q1303* [cytosol]

APC [cytosol]

APC(778-2843) [cytosol]

APC(1-777) [cytosol]

K63polyUb-APC [cytosol]

p-ub-APC [cytosol]

APC [nucleoplasm]

APC E1554* [cytosol]

APC I1417 fs*2 [cytosol]

APC S811* [cytosol]

APC Q1338* [cytosol]

APC F1197* [cytosol]

APC E1544* [cytosol]

APC Q1406* [cytosol]

APC E1397* [cytosol]

APC E1451* [cytosol]

APC S1539* [cytosol]

APC S1392* [cytosol]

APC Q886* [cytosol]

APC Y1376* [cytosol]

APC G1412* [cytosol]

APC S1315* [cytosol]

APC S895* [cytosol]

APC S943* [cytosol]

Modified Residues

Name

Nonsense mutation at L-glutamic acid 1306

Coordinate

1306

PsiMod

L-glutamic acid removal [MOD:01636]

A protein modification that effectively removes or replaces an L-glutamic acid.

Disease

Name	Identifier	Synonyms
colorectal cancer	DOID:9256

Cross References

COSMIC

COSV57322511

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.962	22
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) ub-AXIN1 [cytosol] (R-HSA-4641133) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.845	17
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.825	6
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.816	6
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.802	6
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.738	8
UniProt:Q5JTC6 AMER1	5	AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.723	4
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.697	5
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.669	4
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.668	9
UniProt:Q96N96 SPATA13	1	SPATA13 [cytosol] (R-HSA-9690931)	0.667	5
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.667	4
UniProt:Q9NR80-3 ARHGEF4			0.646	5
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.64	3
UniProt:P14923 JUP	6	JUP [plasma membrane] (R-HSA-437260) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [cornified envelope] (R-HSA-8847739) JUP [cytosol] (R-HSA-201598)	0.64	3
UniProt:Q8N944 AMER3			0.631	8
UniProt:Q02248 Ctnnb1	14	Ctnnb1 [nucleoplasm] (R-MMU-3451168) Ctnnb1 [cytosol] (R-MMU-448839) Ctnnb1 [cytosol] (R-MMU-202930) Ctnnb1 [cytosol] (R-MMU-202950) Ctnnb1 [nucleoplasm] (R-MMU-9735212) Ctnnb1 [plasma membrane] (R-MMU-9038440) Ctnnb1 [plasma membrane] (R-MMU-9761458) phospho-Ctnnb1 [cytosol] (R-MMU-8942374) beta-catenin [cytosol] (R-MMU-206225) phospho-Ctnnb1 [cytosol] (R-MMU-8942369) phospho-Ctnnb1 [cytosol] (R-MMU-8942367) phospho-Ctnnb1 [cytosol] (R-MMU-8942363) phospho-Ctnnb1 [cytosol] (R-MMU-3134933) phospho-Ctnnb1 [nucleoplasm] (R-MMU-3134926)	0.623	8
UniProt:O14640 DVL1	4	ub-DVL1 [cytosol] (R-HSA-4641157) DVL1 [cytosol] (R-HSA-201687) p-S-DVL1 [cytosol] (R-HSA-201700) pp-DVL1 [cytosol] (R-HSA-3772396)	0.623	6
UniProt:Q12959 DLG1	4	DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [cytosol] (R-HSA-416332) DLG1 [plasma membrane] (R-HSA-375977)	0.623	2
UniProt:Q96N96-1 SPATA13			0.619	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.615	3
UniProt:O14936 CASK	1	CASK [cytosol] (R-HSA-373631)	0.59	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:O14641 DVL2	5	DVL2 [cytosol] (R-HSA-201694) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.564	2
UniProt:Q14114 LRP8	2	p-Y-LRP8 [plasma membrane] (R-HSA-432136) LRP8 [plasma membrane] (R-HSA-432113)	0.558	2
UniProt:Q86T90 K1328			0.547	2
UniProt:O14513 NCKP5			0.547	2
UniProt:Q04695 KRT17	1	KRT17 [cytosol] (R-HSA-201583)	0.547	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	2
UniProt:Q16204 CCDC6			0.527	4
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.527	2
UniProt:Q9H9D4 ZN408			0.527	2
UniProt:Q9UI47 CTNA3			0.527	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.527	3
IntAct:EBI-6876712 CTNB1			0.499	6