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APC R876* [cytosol]
Stable Identifier
R-HSA-9666985
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
APC R876TER, Adenomatous polyposis coli protein, APC_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by APC mutants (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
APC truncation mutants [cytosol] (Homo sapiens)
APC R876* [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25054 APC
Gene Names
APC, DP2.5
Chain
initiator methionine:, chain:2-2843
Reference Genes
BioGPS Gene:324 APC
COSMIC (genes):APC APC
CTD Gene:324 APC
dbSNP Gene:324 APC
ENSEMBL:ENSG00000134982 APC
ENSEMBL_homo_sapiens_GENE:ENSG00000134982.18 APC
HGNC:583 APC
KEGG Gene (Homo sapiens):324 APC
Monarch:324 APC
NCBI Gene:324 APC
OMIM:611731 APC
UCSC:P25054 APC
Reference Transcript
RefSeq:NM_001127511.2 APC
RefSeq:NM_001127510.2 APC
RefSeq:NM_000038.5 APC
Other Identifiers
11731561_a_at
11731562_s_at
11757692_s_at
16988021
1912_s_at
203525_PM_s_at
203525_s_at
203526_PM_s_at
203526_s_at
203527_PM_s_at
203527_s_at
216933_3p_x_at
216933_PM_x_at
216933_x_at
2824218
2824220
2824225
2824230
2824232
2824233
2824239
2824244
2824245
2824248
2824253
2824256
2824257
2824258
2824266
2824267
2824268
2824272
2824273
2824274
2824275
2824276
2824277
2824279
324
36182_at
8107330
A_14_P106747
A_14_P116796
A_14_P135872
A_23_P70213
A_33_P3408983
GE58061
GO:0000278
GO:0000281
GO:0000776
GO:0000910
GO:0001708
GO:0003170
GO:0003203
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005874
GO:0005881
GO:0005886
GO:0005912
GO:0005923
GO:0006974
GO:0007010
GO:0007018
GO:0007026
GO:0007059
GO:0007094
GO:0007155
GO:0007389
GO:0007399
GO:0008013
GO:0008017
GO:0008092
GO:0008285
GO:0008286
GO:0012501
GO:0016020
GO:0016043
GO:0016055
GO:0016328
GO:0016342
GO:0016477
GO:0019887
GO:0019901
GO:0023052
GO:0030027
GO:0030154
GO:0030163
GO:0030178
GO:0030335
GO:0030877
GO:0031274
GO:0031625
GO:0032587
GO:0032886
GO:0034330
GO:0036211
GO:0042995
GO:0043065
GO:0043161
GO:0043226
GO:0043229
GO:0045295
GO:0045595
GO:0045732
GO:0045736
GO:0048471
GO:0048856
GO:0048870
GO:0051010
GO:0051988
GO:0060632
GO:0065003
GO:0070161
GO:0070830
GO:0070840
GO:0071944
GO:0090090
GO:0098772
GO:0120162
GO:0140014
GO:1902807
GO:1904781
GO:1990909
GO:2000134
HMNXSV003016363
Hs.75081.0.S2_3p_a_at
Hs.75081.1.S1_3p_a_at
ILMN_1662668
M73548_at
M74088_s_at
PH_hs_0031313
TC05003398.hg
g182396_3p_a_at
g4557318_3p_a_at
Participates
as a candidate of
APC truncation mutants [cytosol] (Homo sapiens)
Other forms of this molecule
APC R213* [cytosol]
APC C1410* [cytosol]
APC K1310* [cytosol]
APC R499* [cytosol]
APC R1450* [cytosol]
APC G1357* [cytosol]
APC L1488* [cytosol]
APC S1400* [cytosol]
APC S1346* [cytosol]
APC R405* [cytosol]
APC S1281* [cytosol]
APC E1573* [cytosol]
APC R805* [cytosol]
APC R1386* [cytosol]
APC S1327* [cytosol]
APC E1209* [cytosol]
APC Q1469* [cytosol]
APC R564* [cytosol]
APC E1536* [cytosol]
APC G1288* [cytosol]
APC G1312* [cytosol]
APC R283* [cytosol]
APC Q1367* [cytosol]
APC E1353* [cytosol]
APC R332* [cytosol]
APC K993* [cytosol]
APC R302* [cytosol]
APC E1309* [cytosol]
APC Y935* [cytosol]
APC E1286* [cytosol]
APC Q1378* [cytosol]
APC R554* [cytosol]
APC S1356* [cytosol]
APC R232* [cytosol]
APC E1379* [cytosol]
APC E984* [cytosol]
APC R1114* [cytosol]
APC S1282* [cytosol]
APC Q1328* [cytosol]
APC E1295* [cytosol]
APC E1151* [cytosol]
APC E1322* [cytosol]
APC E1345* [cytosol]
APC K1308* [cytosol]
APC S1344* [cytosol]
APC E1577* [cytosol]
APC Q1127* [cytosol]
APC E1464* [cytosol]
APC E1317* [cytosol]
APC G1309Dfs*4 [cytosol]
APC W1049* [cytosol]
APC Q1429* [cytosol]
APC L1564* [cytosol]
APC Q1294* [cytosol]
APC K1363* [cytosol]
APC E1408* [cytosol]
APC E1284* [cytosol]
APC E1374* [cytosol]
APC Q767* [cytosol]
APC E941* [cytosol]
APC Q1303* [cytosol]
APC S943* [cytosol]
APC E1306* [cytosol]
APC S895* [cytosol]
APC S1315* [cytosol]
APC G1412* [cytosol]
APC Y1376* [cytosol]
APC Q886* [cytosol]
APC S1392* [cytosol]
APC S1539* [cytosol]
APC E1451* [cytosol]
APC E1397* [cytosol]
APC Q1406* [cytosol]
APC E1544* [cytosol]
APC F1197* [cytosol]
APC Q1338* [cytosol]
APC S811* [cytosol]
APC I1417 fs*2 [cytosol]
APC E1554* [cytosol]
APC [nucleoplasm]
p-ub-APC [cytosol]
K63polyUb-APC [cytosol]
APC(1-777) [cytosol]
APC(778-2843) [cytosol]
APC [cytosol]
Modified Residues
Name
Nonsense mutation at L-arginine 876
Coordinate
876
PsiMod
L-arginine removal [MOD:01632]
A protein modification that effectively removes or replaces an L-arginine.
Disease
Name
Identifier
Synonyms
colorectal cancer
DOID:9256
Cross References
RefSeq
NP_001120982.1
,
NP_001120983.2
,
NP_000029.2
COSMIC
COSV57320538
OpenTargets
ENSG00000134982
HPA
ENSG00000134982-APC
GeneCards
P25054
Ensembl
ENSP00000427089
,
ENSG00000134982
,
ENSP00000257430
,
ENST00000508376
,
ENST00000257430
PRO
P25054
Pharos - Targets
P25054
Orphanet
16443
PDB
4YJL
,
2RQU
,
3QHE
,
1EMU
,
7F7O
,
3RL7
,
3NMW
,
3AU3
,
8X2Q
,
5IZA
,
1M5I
,
3T7U
,
4G69
,
1JPP
,
7F6M
,
4YK6
,
5Z8H
,
5IZ6
,
1DEB
,
8GSJ
,
3NMZ
,
5IZ8
,
4YJE
,
1T08
,
1V18
,
5IZ9
,
7XTY
,
3RL8
,
1TH1
,
5B6G
,
3NMX
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.962
22
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
AXIN1 [cytosol]
(R-HSA-195249)
0.845
17
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.825
6
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.816
6
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.802
6
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.738
8
UniProt:Q5JTC6 AMER1
5
AMER1 [cytosol]
(R-HSA-1504189)
AMER1 R353* [cytosol]
(R-HSA-9663939)
AMER1 R358* [cytosol]
(R-HSA-4839640)
AMER1 S210* [cytosol]
(R-HSA-5251492)
AMER1 R497* [cytosol]
(R-HSA-9663943)
0.723
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.697
5
UniProt:Q9NSA3 CTNNBIP1
1
CTNNBIP1 [nucleoplasm]
(R-HSA-3772388)
0.669
4
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.668
9
UniProt:Q96N96 SPATA13
1
SPATA13 [cytosol]
(R-HSA-9690931)
0.667
5
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.667
4
UniProt:Q9NR80-3 ARHGEF4
0.646
5
UniProt:P35221 CTNNA1
2
CTNNA1 [cytosol]
(R-HSA-191697)
CTNNA1 [plasma membrane]
(R-HSA-191735)
0.64
3
UniProt:P14923 JUP
6
JUP [cytosol]
(R-HSA-201598)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [plasma membrane]
(R-HSA-437260)
0.64
3
UniProt:Q8N944 AMER3
0.631
8
UniProt:O14640 DVL1
4
pp-DVL1 [cytosol]
(R-HSA-3772396)
p-S-DVL1 [cytosol]
(R-HSA-201700)
DVL1 [cytosol]
(R-HSA-201687)
ub-DVL1 [cytosol]
(R-HSA-4641157)
0.623
6
UniProt:Q12959 DLG1
4
DLG1 [cytosol]
(R-HSA-416332)
DLG1 [endoplasmic reticulum membrane]
(R-HSA-9610593)
DLG1 [transport vesicle membrane]
(R-HSA-9610631)
DLG1 [plasma membrane]
(R-HSA-375977)
0.623
2
UniProt:Q02248 Ctnnb1
14
phospho-Ctnnb1 [cytosol]
(R-MMU-3134933)
phospho-Ctnnb1 [nucleoplasm]
(R-MMU-3134926)
Ctnnb1 [plasma membrane]
(R-MMU-9761458)
Ctnnb1 [plasma membrane]
(R-MMU-9038440)
Ctnnb1 [nucleoplasm]
(R-MMU-3451168)
Ctnnb1 [cytosol]
(R-MMU-448839)
Ctnnb1 [cytosol]
(R-MMU-202930)
Ctnnb1 [cytosol]
(R-MMU-202950)
Ctnnb1 [nucleoplasm]
(R-MMU-9735212)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942374)
beta-catenin [cytosol]
(R-MMU-206225)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942369)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942367)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942363)
0.623
8
UniProt:Q96N96-1 SPATA13
0.619
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.615
3
UniProt:O14936 CASK
1
CASK [cytosol]
(R-HSA-373631)
0.59
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.564
2
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.564
2
UniProt:Q14114 LRP8
2
p-Y-LRP8 [plasma membrane]
(R-HSA-432136)
LRP8 [plasma membrane]
(R-HSA-432113)
0.558
2
UniProt:Q86T90 K1328
0.547
2
UniProt:O14513 NCKP5
0.547
2
UniProt:Q04695 KRT17
1
KRT17 [cytosol]
(R-HSA-201583)
0.547
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.536
2
UniProt:Q16204 CCDC6
0.527
4
UniProt:Q9NUP9 LIN7C
2
LIN7C [plasma membrane]
(R-HSA-5216165)
LIN7C [transport vesicle membrane]
(R-HSA-9610411)
0.527
2
UniProt:Q9H9D4 ZN408
0.527
2
UniProt:Q9UI47 CTNA3
0.527
3
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.527
3
IntAct:EBI-6876712 CTNB1
0.499
6
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