ANKLE2 is deacetylated by SIRT2

Stable Identifier
R-HSA-9667952
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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ANKLE2 is deacetylated by SIRT2
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ANKLE2 (LEM4) is required for normal nuclear envelope (NE) formation at the end of mitosis (Ascencio et al. 2012, Kaufmann et al. 2016). Deacetylation of ANKLE2 on residue K302 by SIRT2 promotes this process (Kaufman et al. 2016).
Literature References
PubMed ID Title Journal Year
27875273 SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation

Kostrhon, S, Kukolj, E, Opravil, S, Slade, D, Brachner, A, Kaufmann, T, Mechtler, K, Beltzung, E, Hudecz, O, Bruno, M, Warren, G

J. Cell. Sci. 2016
22770216 Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis

Wallenfang, MR, Mall, M, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Asencio, C, Gorjánácz, M, Mattaj, IW

Cell 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

NAD-dependent protein deacetylase activity of SIRT2 [cytosol]

Physical Entity
SIRT2 [cytosol] (Homo sapiens)
Activity
NAD-dependent protein deacetylase activity (GO:0034979)
Orthologous Events
ANKLE2 is deacetylated by SIRT2 (Bos taurus)
ANKLE2 is deacetylated by SIRT2 (Canis familiaris)
ANKLE2 is deacetylated by SIRT2 (Danio rerio)
ANKLE2 is deacetylated by SIRT2 (Drosophila melanogaster)
ANKLE2 is deacetylated by SIRT2 (Gallus gallus)
ANKLE2 is deacetylated by SIRT2 (Mus musculus)
ANKLE2 is deacetylated by SIRT2 (Rattus norvegicus)
ANKLE2 is deacetylated by SIRT2 (Sus scrofa)
Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2019-11-18)
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