SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin

Stable Identifier
R-HSA-9668405
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, nuclear envelope
ReviewStatus
5/5
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SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin
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Spastin (SPAST), an AAA+ ATPase that severs microtubules attached to the chromosome surfaces, binds the ESCRT-III subunit IST1 (Vietri et al. 2015).
Literature References
PubMed ID Title Journal Year
26040712 Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

Campsteijn, C, Schultz, SW, Schink, KO, Wegner, CS, Brech, A, Christ, L, Raiborg, C, Thoresen, SB, Stenmark, H, Vietri, M

Nature 2015
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Orthologous Events
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Bos taurus)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Caenorhabditis elegans)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Canis familiaris)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Danio rerio)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Dictyostelium discoideum)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Drosophila melanogaster)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Gallus gallus)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Mus musculus)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Rattus norvegicus)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Sus scrofa)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Xenopus tropicalis)
Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2019-11-25)
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