VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope

Stable Identifier
R-HSA-9668415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nuclear envelope
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VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
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The AAA+ ATPase action of VPS4 causes reorganization/disassembly of ESCRT-III filaments, which leads to membrane fusion and sealing of nuclear envelope holes (Vietri et al. 2015).

Literature References
PubMed ID Title Journal Year
26040712 Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

Vietri, M, Schink, KO, Campsteijn, C, Wegner, CS, Schultz, SW, Christ, L, Thoresen, SB, Brech, A, Raiborg, C, Stenmark, H

Nature 2015
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ATPase activity of LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope]
Physical Entity
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope]
Activity
ATPase activity (0016887)
Orthologous Events
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Caenorhabditis elegans)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Sus scrofa)
Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2019-11-25)
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