SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

Stable Identifier
R-HSA-9668419
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The AAA+ ATPase activity of spastin (SPAST) removes attached microtubules from chromosomes, allowing formation of a sealed nuclear envelope (Vietri et al. 2015, Ventimiglia et al. 2018).
Literature References
PubMed ID Title Journal Year
30513301 CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope

Olmos, Y, Cuesta-Geijo, MA, Ventimiglia, LN, Carlton, JG, Miguet, N, Macheboeuf, P, Weissenhorn, W, Parnham, IM, Martinelli, N, Caballe, A, Martin-Serrano, J

Dev. Cell 2018
26040712 Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

Campsteijn, C, Schultz, SW, Schink, KO, Wegner, CS, Brech, A, Christ, L, Raiborg, C, Thoresen, SB, Stenmark, H, Vietri, M

Nature 2015
Participants
Participates
Catalyst Activity

microtubule-severing ATPase activity of LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope]

Orthologous Events
Authored
Created
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