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NBEA binds PRKAR2A
Stable Identifier
R-HSA-9668558
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
PKA-mediated phosphorylation of CREB (Homo sapiens)
PKA activation (Homo sapiens)
NBEA binds PRKAR2A (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
PKA-mediated phosphorylation of CREB (Homo sapiens)
PKA activation (Homo sapiens)
NBEA binds PRKAR2A (Homo sapiens)
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NBEA (neurobeachin) binds to the regulatory subunit of PKA, PRKAR2A (PKA RIIalpha). This binding may be involved in localizing PKA to specific subcellular regions, e.g. postsynaptic density in neurons (Wang et al. 2000), but the experimental evidence is not conclusive. Mice that are heterozygous for NBEA gene knockout have NBEA haploinsufficiency and show aberrant PKA activity and changes in platelet morphology (Nuytens et al. 2013). PRKAR2A-binding domain of NBEA is not essential for NBEA-mediated targeting of glutamate and GABA receptors to the synapse (Farzana et al. 2016).
Participants
Input
NBEA [cytosol]
(Homo sapiens)
PRKAR2A [cytosol]
(Homo sapiens)
Output
NBEA:PRKAR2A [cytosol]
(Homo sapiens)
Participates
as an event of
PKA activation (Homo sapiens)
Inferred From
Nbea binds Prkar2a (Rattus norvegicus)
Authored
Orlic-Milacic, M (2020-01-07)
Reviewed
Miller, AC (2020-02-10)
Martin, EA (2020-02-10)
Created
Orlic-Milacic, M (2019-11-28)
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