Reactome | SMAD3 E246* [cytosol]

SMAD3 E246* [cytosol]

Stable Identifier

R-HSA-9668776

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SMAD3 E246TER, SMAD3 Glu246*, SMAD3 Glu246TER

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
    - Loss of Function of SMAD2/3 in Cancer (Homo sapiens)
      - SMAD2/3 Phosphorylation Motif Mutants in Cancer (Homo sapiens)
        
        Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)
        
        TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 Phosphorylation Motif Mutants [early endosome membrane] (Homo sapiens)
        
        SMAD2/3 Phosphorylation Motif Mutants [cytosol] (Homo sapiens)
        
        SMAD3 Phosphorylation Motif Mutants [cytosol] (Homo sapiens)
        
        SMAD3 E246* [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P84022 SMAD3

Gene Names

SMAD3, MADH3

Chain

initiator methionine:1, chain:2-425

Reference Genes

BioGPS Gene:4088 SMAD3

COSMIC (genes):SMAD3 SMAD3

CTD Gene:4088 SMAD3

dbSNP Gene:4088 SMAD3

ENSEMBL:ENSG00000166949 SMAD3

HGNC:6769 SMAD3

KEGG Gene (Homo sapiens):4088 SMAD3

Monarch:4088 SMAD3

NCBI Gene:4088 SMAD3

OMIM:603109 SMAD3

UCSC:P84022 SMAD3

Reference Transcript

Other Identifiers

0000380136

0005860086

11718265_a_at

11718266_s_at

11726549_a_at

11751185_a_at

11754091_s_at

1433_g_at

1454_at

1950_s_at

205396_at

205397_x_at

205398_s_at

218284_at

3598960

3598961

3598977

3598984

3598992

3598993

3598994

3598995

3598997

3598999

3599014

3599016

3599023

3599028

3599029

3599030

3599031

3599032

3599033

3599034

3599035

3599036

3599037

3599038

3599039

3599040

3599041

3599042

38944_at

4088

44841_at

44986_s_at

51059_at

58763_at

65983_at

7984364

A_14_P107358

A_23_P48936

GE56446

GE79350

GO:0000122

GO:0000228

GO:0000278

GO:0000790

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001102

GO:0001223

GO:0001228

GO:0001501

GO:0001649

GO:0001657

GO:0001666

GO:0001701

GO:0001707

GO:0001756

GO:0001889

GO:0001947

GO:0002076

GO:0002376

GO:0002520

GO:0003013

GO:0003674

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0005160

GO:0005515

GO:0005518

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005637

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006357

GO:0006464

GO:0006810

GO:0006913

GO:0006919

GO:0006950

GO:0006955

GO:0007010

GO:0007049

GO:0007050

GO:0007155

GO:0007165

GO:0007179

GO:0007183

GO:0007267

GO:0007369

GO:0007492

GO:0008013

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0008283

GO:0008285

GO:0009056

GO:0009058

GO:0009790

GO:0009880

GO:0010628

GO:0010694

GO:0010718

GO:0015031

GO:0016032

GO:0016202

GO:0016579

GO:0017015

GO:0017151

GO:0019899

GO:0019901

GO:0019902

GO:0022607

GO:0023019

GO:0030154

GO:0030198

GO:0030308

GO:0030325

GO:0030335

GO:0030501

GO:0030512

GO:0030878

GO:0031053

GO:0031490

GO:0031625

GO:0031962

GO:0032182

GO:0032332

GO:0032731

GO:0032909

GO:0032916

GO:0032924

GO:0032991

GO:0033689

GO:0034330

GO:0034641

GO:0035259

GO:0038092

GO:0040007

GO:0040011

GO:0042060

GO:0042110

GO:0042177

GO:0042307

GO:0042592

GO:0042802

GO:0042803

GO:0043066

GO:0043130

GO:0043167

GO:0043226

GO:0043235

GO:0043425

GO:0043565

GO:0044403

GO:0045216

GO:0045429

GO:0045599

GO:0045668

GO:0045893

GO:0045930

GO:0045944

GO:0046332

GO:0046872

GO:0048340

GO:0048589

GO:0048617

GO:0048646

GO:0048701

GO:0048856

GO:0048870

GO:0050678

GO:0050728

GO:0050776

GO:0050821

GO:0050927

GO:0051091

GO:0051098

GO:0051481

GO:0051496

GO:0051894

GO:0060039

GO:0060290

GO:0060395

GO:0061045

GO:0061767

GO:0065003

GO:0070306

GO:0070410

GO:0070412

GO:0071141

GO:0071144

GO:0071345

GO:0071560

GO:0090263

GO:0097191

GO:0097296

GO:1901203

GO:1902895

GO:1903243

Hs.211578.0.S3_3p_at

ILMN_1682738

PH_hs_0032513

PH_hs_0039929

TC15000622.hg

TC15002251.hg

U68019_at

g1673576_3p_s_at

g5174512_3p_s_at

g7661691_3p_at

Participant Of

hasCandidate

SMAD3 Phosphorylation Motif Mutants [cytosol]

Other forms of this molecule

Ub-SMAD3 [cytosol]

p-S423,S425-SMAD3 D258N [cytosol]

p-S423,S425-SMAD3 R268C [cytosol]

p-S423,S425-SMAD3 R268H [cytosol]

SMAD3 Q316* [cytosol]

SMAD3 Y384* [cytosol]

SMAD3 W326* [cytosol]

SMAD3 Q358* [cytosol]

SMAD3 Q322* [cytosol]

SMAD3 S425F [cytosol]

SMAD3 E383* [cytosol]

SMAD3 R368* [cytosol]

SMAD3 Y298* [cytosol]

SMAD3 S425C [cytosol]

2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]

p-T179,S423,S425-SMAD3 [nucleoplasm]

SMAD3 [nucleoplasm]

SMAD3 [cytosol]

p-S423,S425-SMAD3 [nucleoplasm]

p-S423,S425-SMAD3 [cytosol]

Modified Residues

Name

L-glutamic acid 246 replaced with unknown

Coordinate

246

PsiMod

L-glutamic acid removal [MOD:01636]

A protein modification that effectively removes or replaces an L-glutamic acid.

Disease

Name	Identifier	Synonyms
large intestine cancer	5672	malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
cancer	162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_001138575.1, NP_001138576.1, NP_001138574.1, NP_005893.1

COSMIC

COSM6023580

OpenTargets

ENSG00000166949

GeneCards

P84022

HPA

ENSG00000166949-SMAD3

Ensembl

ENSG00000166949, ENST00000327367, ENST00000540846, ENSP00000445348, ENSP00000401133, ENST00000439724, ENSP00000437757, ENSP00000332973, ENST00000537194

PRO

P84022

Orphanet

19833

PDB

5ODG, 1MHD, 2LB2, 5OD6, 1OZJ, 2LAJ, 5XOC, 1U7F, 1MK2, 1MJS

Interactors (65)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	88	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622) SMAD4 E417* [cytosol] (R-HSA-9675623) SMAD4 Y195* [cytosol] (R-HSA-9678462) SMAD4 E108* [cytosol] (R-HSA-9675640) SMAD4 S343* [cytosol] (R-HSA-9675641) SMAD4 E520* [cytosol] (R-HSA-9675636) SMAD4 G510* [cytosol] (R-HSA-9678452) SMAD4 G358* [cytosol] (R-HSA-9678453) SMAD4 E175* [cytosol] (R-HSA-9675637) SMAD4 E307* [cytosol] (R-HSA-9675639) SMAD4 E53* [cytosol] (R-HSA-9675633) SMAD4 S171* [cytosol] (R-HSA-9675634) SMAD4 G30* [cytosol] (R-HSA-9678450) SMAD4 G168* [cytosol] (R-HSA-9678451) SMAD4 Q366* [cytosol] (R-HSA-9675200) SMAD4 R135* [cytosol] (R-HSA-9675090) SMAD4 L146* [cytosol] (R-HSA-9678509) SMAD4 L440* [cytosol] (R-HSA-9678510) SMAD4 Q183* [cytosol] (R-HSA-9675176) SMAD4 Q289* [cytosol] (R-HSA-9675177) SMAD4 Q248* [cytosol] (R-HSA-9675178) SMAD4 Q249* [cytosol] (R-HSA-9675172) SMAD4 Q256* [cytosol] (R-HSA-9675173) SMAD4 Q239* [cytosol] (R-HSA-9675174) SMAD4 Q245* [cytosol] (R-HSA-9675175) SMAD4 Q224* [cytosol] (R-HSA-9675168) SMAD4 W509* [cytosol] (R-HSA-9678497) SMAD4 Q311* [cytosol] (R-HSA-9675169) SMAD4 W398* [cytosol] (R-HSA-9678498) SMAD4 Q250* [cytosol] (R-HSA-9675170) SMAD4 Q410* [cytosol] (R-HSA-9675196) SMAD4 Q534* [cytosol] (R-HSA-9675197) SMAD4 Q83* [cytosol] (R-HSA-9675199) SMAD4 Q448* [cytosol] (R-HSA-9675192) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 Q455* [cytosol] (R-HSA-9675193) SMAD4 R445* [cytosol] (R-HSA-9675065) SMAD4 Q442* [cytosol] (R-HSA-9675194) SMAD4 Q516* [cytosol] (R-HSA-9675195) SMAD4 C443* [cytosol] (R-HSA-9678523) SMAD4 Q334* [cytosol] (R-HSA-9675191) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 L172* [cytosol] (R-HSA-9678514) SMAD4 K122* [cytosol] (R-HSA-9678515) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 Y430* [cytosol] (R-HSA-9678476) SMAD4 Y260* [cytosol] (R-HSA-9678477) SMAD4 Y95* [cytosol] (R-HSA-9678478) SMAD4 Y322* [cytosol] (R-HSA-9678479) SMAD4 E321* [cytosol] (R-HSA-9675658) SMAD4 Y412* [cytosol] (R-HSA-9678469) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 Y328* [cytosol] (R-HSA-9678470) SMAD4 E33* [cytosol] (R-HSA-9675654) SMAD4 Y513* [cytosol] (R-HSA-9678471) SMAD4 E526* [cytosol] (R-HSA-9675648) SMAD4 S138* [cytosol] (R-HSA-9675649) SMAD4 Y276* [cytosol] (R-HSA-9678466) SMAD4 E205* [cytosol] (R-HSA-9675650) SMAD4 E49* [cytosol] (R-HSA-9675651) SMAD4 W101* [cytosol] (R-HSA-9678492) SMAD4 W268* [cytosol] (R-HSA-9678494) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 W524* [cytosol] (R-HSA-9678491) SMAD4 W302* [cytosol] (R-HSA-9678490) SMAD4 S242* [cytosol] (R-HSA-9675167) SMAD4 Q116* [cytosol] (R-HSA-9675166)	0.979	33
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.842	11
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.805	9
UniProt:Q9H0M0 WWP1	1	WWP1 [cytosol] (R-HSA-976037)	0.805	9
UniProt:Q9HAU4 SMURF2	2	SMURF2 [nucleoplasm] (R-HSA-178202) SMURF2 [cytosol] (R-HSA-173537)	0.799	8
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.779	7
UniProt:O95405 ZFYVE9			0.764	5
UniProt:P50222 MEOX2			0.718	6
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.69	5
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.675	4
UniProt:O43524 FOXO3	9	p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413)	0.667	5
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.666	4
UniProt:P84022 SMAD3	21	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) SMAD3 [nucleoplasm] (R-HSA-206150) SMAD3 [cytosol] (R-HSA-170855) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184)	0.656	3
UniProt:Q64729	3	Tgfbr1 [plasma membrane] (R-MMU-170839) Tgfbr1 [plasma membrane] (R-MMU-8869461) phospho-Tgfbr1 [plasma membrane] (R-MMU-170849)	0.576	6
UniProt:Q9BZ29 DOCK9	1	DOCK9 [cytosol] (R-HSA-1012981)	0.576	3
UniProt:Q15796 SMAD2	27	p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 Q429* [cytosol] (R-HSA-9668727) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) SMAD2 [nucleoplasm] (R-HSA-3006352) SMAD2 [cytosol] (R-HSA-3006353) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185)	0.573	2
UniProt:Q99814 EPAS1	5	2xHP-EPAS1 [cytosol] (R-HSA-1234149) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) HN-EPAS1 [cytosol] (R-HSA-1234112) EPAS1 [cytosol] (R-HSA-1234119) EPAS1 [nucleoplasm] (R-HSA-452560)	0.573	2
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.573	2
UniProt:Q9Y2U8 LEMD3	1	LEMD3 [nuclear envelope] (R-HSA-2993886)	0.564	2
UniProt:P10070 GLI2	11	p8S-GLI2 [ciliary base] (R-HSA-5610494) p4S-GLI2 [ciliary base] (R-HSA-5610487) p11S-GLI2 [ciliary base] (R-HSA-5610471) ub-p11S-GLI2 [ciliary base] (R-HSA-5610501) GLI2 [ciliary tip] (R-HSA-5610363) GLI2 [ciliary base] (R-HSA-5610361) 2p-GLI2 [nucleoplasm] (R-HSA-5635055) p-GLI2 [nucleoplasm] (R-HSA-5635047) p-GLI2 [ciliary tip] (R-HSA-5635044) GLI2 [cytosol] (R-HSA-445451) ub-2p-GLI2 [nucleoplasm] (R-HSA-5635059)	0.558	4
UniProt:P46934-3 NEDD4			0.556	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:P29466-3 CASP1			0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:P20618 PSMB1	5	PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.556	3
UniProt:Q8N684-3 CPSF7			0.556	3
UniProt:P0C264 SBK3			0.556	3
UniProt:E9PSE9 E9PSE9			0.556	3
UniProt:Q8IXK0-5 PHC2			0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.556	3
IntAct:EBI-11522976 CCDC33			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q8WW24 TEKT4			0.556	3
UniProt:Q8N684 CPSF7	1	CPSF7 [nucleoplasm] (R-HSA-72012)	0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [cytosol] (R-HSA-445368) p-T286-CAMK2A [plasma membrane] (R-HSA-432796) CAMK2A [cytosol] (R-HSA-4332329) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797)	0.556	3
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:P17612 PRKACA	3	PRKACA [cytosol] (R-HSA-57844) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P15822 ZEP1			0.553	2
UniProt:O15397 IPO8	2	IPO8 [cytosol] (R-HSA-5578740) IPO8 [nucleoplasm] (R-HSA-5578747)	0.544	2
UniProt:Q99836 MYD88	9	MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329) MYD88 [cytosol] (R-HSA-193946) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059) MYD88 [endosome membrane] (R-HSA-975123) MyD88 E65del [cytosol] (R-HSA-5602598) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 L93P [cytosol] (R-HSA-5602612)	0.543	3
UniProt:Q13501 SQSTM1	2	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961)	0.543	3
UniProt:P51141 Dvl1	4	Dvl1 [cytosol] (R-MMU-1504179) Dvl1 [cytosol] (R-MMU-4641157) phospho-Dvl1 [cytosol] (R-MMU-201700) phospho-Dvl1 [cytosol] (R-MMU-3772396)	0.527	2
UniProt:Q9NYA4 MTMR4	2	MTMR4 [cytosol] (R-HSA-1604658) MTMR4 [early endosome membrane] (R-HSA-2187404)	0.524	2
UniProt:P98082 DAB2	3	DAB2 [lysosomal membrane] (R-HSA-2980807) DAB2 [cytosol] (R-HSA-8862456) DAB2 [plasma membrane] (R-HSA-2980808)	0.524	3
UniProt:Q9BYW2 SETD2	1	SETD2 [nucleoplasm] (R-HSA-1183220)	0.508	2
UniProt:Q9H2X0 CHRD			0.508	2
UniProt:Q9BZL4 PP12C			0.508	2
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.508	2
UniProt:Q9Y3Q8 T22D4			0.508	2
UniProt:Q16822 PCK2	1	PCK2 [mitochondrial matrix] (R-HSA-372815)	0.508	2
UniProt:Q5D1E8 ZC12A			0.508	2
UniProt:P17844 DDX5	4	DDX5 [cytosol] (R-HSA-9682643) DDX5 [nucleoplasm] (R-HSA-3900136) SUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) SUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.499	2
UniProt:Q05066 SRY	1	SRY [nucleoplasm] (R-HSA-5627706)	0.499	3
UniProt:P23142 FBLN1	1	FBLN1 [extracellular region] (R-HSA-2161389)	0.488	2
UniProt:Q93062-3 RBPMS			0.488	2
UniProt:Q9NZH6 IL37	6	IL37(?-218) [extracellular region] (R-HSA-9008607) IL37(?-218) [nucleoplasm] (R-HSA-9008702) IL37 [extracellular region] (R-HSA-8848334) IL37(?-218) [cytosol] (R-HSA-9008584) IL37 [cytosol] (R-HSA-9008596) IL37(1-?) [cytosol] (R-HSA-9008602)	0.463	2
UniProt:Q16665 HIF1A	7	2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) HN-HIF1A [cytosol] (R-HSA-1234110) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.463	6

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