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TEN1 [nucleoplasm]
Stable Identifier
R-HSA-9668823
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CST complex subunit TEN1, TEN1L_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
Telomere C-strand synthesis initiation (Homo sapiens)
CST complex formation (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
CST complex [nucleoplasm] (Homo sapiens)
TEN1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86WV5 TEN1
Gene Names
TEN1, C17orf106
Chain
chain:1-123
Reference Genes
BioGPS Gene:100134934 TEN1
COSMIC (genes):TEN1 TEN1
CTD Gene:100134934 TEN1
dbSNP Gene:100134934 TEN1
ENSEMBL:ENSG00000257949 TEN1
HGNC:37242 TEN1
KEGG:hsa:100134934 TEN1
Monarch:100134934 TEN1
NCBI Gene:100134934 TEN1
OMIM:613130 TEN1
UCSC:Q86WV5 TEN1
Reference Transcript
RefSeq:NM_001113324.2 TEN1
Other Identifiers
100134934
11720076_at
226396_PM_at
226396_at
3735347
3735348
3735349
3735350
3735351
3735353
3735354
3735355
3735356
3735361
48516_at
8010012
8010017
A_33_P3337491
GO:0000781
GO:0003677
GO:0003697
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0010521
GO:0016233
GO:0032200
GO:0032211
GO:0042162
GO:0043226
GO:0098772
GO:1990879
HMNXSV003044873
Hs.100009.1.S1_3p_at
Participates
as an input of
CST complex formation (Homo sapiens)
as a component of
CST complex [nucleoplasm] (Homo sapiens)
Inferred To
Ten1 [nucleoplasm]
(Mus musculus)
Ten1 [nucleoplasm]
(Rattus norvegicus)
TEN1 [nucleoplasm]
(Bos taurus)
TEN1 [nucleoplasm]
(Canis familiaris)
TEN1 [nucleoplasm]
(Gallus gallus)
TEN1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001106795.2
OpenTargets
ENSG00000257949
ENSEMBL
ENSP00000380762
,
ENST00000397640
HPA
ENSG00000257949-TEN1
PRO
Q86WV5
Pharos - Targets
Q86WV5
PDB
8SOK
,
8D0K
,
8SOJ
,
8D0B
,
7U5C
,
4JOI
,
6W6W
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H668 STN1
1
STN1 [nucleoplasm]
(R-HSA-9668821)
0.876
13
UniProt:Q2NKJ3 CTC1
1
CTC1 [nucleoplasm]
(R-HSA-9668825)
0.708
5
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:P41219 PERI
0.556
3
UniProt:O43464 HTRA2
1
HTRA2 [mitochondrial intermembrane space]
(R-HSA-56655)
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:O14901 KLF11
0.556
3
UniProt:P55212 CASP6
5
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:P62826 RAN
2
RAN [cytosol]
(R-HSA-165540)
RAN [nucleoplasm]
(R-HSA-165528)
0.556
3
UniProt:Q9BVL2 NUP58
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:Q14957 GRIN2C
3
GRIN2C [plasma membrane]
(R-HSA-419560)
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
0.556
3
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:O75400-2 PRPF40A
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
0.556
3
UniProt:P60891 PRPS1
1
PRPS1 [cytosol]
(R-HSA-73483)
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:Q2NKJ3-1 CTC1
0.499
2
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