Reactome | TEN1 [nucleoplasm]

TEN1 [nucleoplasm]

Stable Identifier

R-HSA-9668823

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CST complex subunit TEN1, TEN1L_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P22607

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Cell Cycle (Homo sapiens)

- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Extension of Telomeres (Homo sapiens)
      - Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
        
        Telomere C-strand synthesis initiation (Homo sapiens)
        
        CST complex formation (Homo sapiens)
        
        TEN1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86WV5 TEN1

Gene Names

TEN1, C17orf106

Chain

chain:1-123

Reference Genes

BioGPS Gene:100134934 TEN1

COSMIC (genes):TEN1 TEN1

CTD Gene:100134934 TEN1

dbSNP Gene:100134934 TEN1

ENSEMBL:ENSG00000257949 TEN1

HGNC:37242 TEN1

KEGG Gene (Homo sapiens):100134934 TEN1

Monarch:100134934 TEN1

NCBI Gene:100134934 TEN1

OMIM:613130 TEN1

UCSC:Q86WV5 TEN1

Reference Transcript

RefSeq:NM_001113324.2 TEN1

Other Identifiers

0106940402

100134934

11720076_at

226396_at

3735347

3735349

3735350

3735351

3735353

3735354

3735355

3735356

3735361

48516_at

8010012

8010017

A_33_P3337491

GO:0000781

GO:0003674

GO:0003677

GO:0003697

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006259

GO:0008150

GO:0009058

GO:0010521

GO:0016233

GO:0030234

GO:0032211

GO:0032991

GO:0034641

GO:0042162

GO:0042592

GO:0043226

GO:0051276

GO:0051974

GO:1990879

HMNXSV003044873

Hs.100009.1.S1_3p_at

ILMN_3239959

Participates

as an input of

CST complex formation (Homo sapiens)

as a component of

CST complex [nucleoplasm] (Homo sapiens)

Inferred To

Ten1 [nucleoplasm] (Mus musculus)

Ten1 [nucleoplasm] (Rattus norvegicus)

ten1 [nucleoplasm] (Danio rerio)

CDK3 [nucleoplasm] (Sus scrofa)

TEN1 [nucleoplasm] (Canis familiaris)

TEN1 [nucleoplasm] (Gallus gallus)

Cross References

RefSeq

NP_001106795.2

OpenTargets

ENSG00000257949

GeneCards

Q86WV5

HPA

ENSG00000257949-TEN1

Ensembl

ENSG00000257949, ENST00000397640, ENSP00000380762

PRO

Q86WV5

PDB

6W6W, 4JOI

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H668 STN1	1	STN1 [nucleoplasm] (R-HSA-9668821)	0.837	11
UniProt:Q2NKJ3 CTC1	1	CTC1 [nucleoplasm] (R-HSA-9668825)	0.623	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.556	3
UniProt:P22607 FGFR3	40	FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) pY-FGFR3 [plasma membrane] (R-HSA-2038368) p-6Y-FGFR3 K650Q [plasma membrane] (R-HSA-2032962) p-6Y-FGFR3 K650N [plasma membrane] (R-HSA-2032961) p-6Y-FGFR3 K650E [plasma membrane] (R-HSA-2032952) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853147) p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853155) p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853145) p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853129) p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853151) p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853128) FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127)	0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:Q14957 GRIN2C	3	p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:Q9BVL2 NUP58			0.556	3
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P55212 CASP6	5	CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:O43464 HTRA2			0.556	3
UniProt:P41219 PERI			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q2NKJ3-1 CTC1			0.499	2

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