Reactome | KIT binds type I TKIs

KIT binds type I TKIs

Stable Identifier

R-HSA-9669893

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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KIT can be bound and inhibited by class I tyrosine kinase inhibitors including dovitinib and midostaurin, among others. Type I inhibitors bind in the ATP binding site of the active conformation and prevent activation of the kinase (reviewed in Roskoski, 2018; Abbbaspour Babaei et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
27536065	Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells Abbaspour Babaei, M, Kamalidehghan, B, Saleem, M, Huri, HZ, Ahmadipour, F	Drug Des Devel Ther	2016
29704617	The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders Roskoski, R	Pharmacol. Res.	2018