JAK2 binds to p-KIT mutants

Stable Identifier
R-HSA-9670413
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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JAK2 binds to p-KIT mutants
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Activation of STAT signaling has been observed downstream of a number of oncogenic KIT mutants, both juxtamembrane and kinase domain mutants, although the biological relevance or each STAT isoform varies between tumor types (Brizzi et al, 1999; Ning et al, 2001; Frost et al, 2002; Growney et al, 2005; Hana et al, 2017; Obata et al, 2017; Duensing et al, 2004; Bauer et al, 2007; Deberry et al, 1997; Ronnstrand, 2004). Although the pathway details haven't been examined in all cases, this likely occurs through the recruitment of JAK2 and SRC family kinases, as is the case for the wild type receptor (reviewed in Lennartsson and Roonstrand, 2012).
Literature References
PubMed ID Title Journal Year
23073628 Stem cell factor receptor/c-Kit: from basic science to clinical implications

Lennartsson, J, Rönnstrand, L

Physiol. Rev. 2012
28192400 Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors

Obata, Y, Horikawa, K, Takahashi, T, Akieda, Y, Tsujimoto, M, Fletcher, JA, Esumi, H, Nishida, T, Abe, R

Oncogene 2017
10358045 STAT protein recruitment and activation in c-Kit deletion mutants

Brizzi, MF, Dentelli, P, Rosso, A, Yarden, Y, Pegoraro, L

J Biol Chem 1999
9438854 Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

Hirota, S, Isozaki, K, Moriyama, Y, Hashimoto, K, Nishida, T, Ishiguro, S, Kawano, K, Hanada, M, Kurata, A, Takeda, M, Muhammad Tunio, G, Matsuzawa, Y, Kanakura, Y, Shinomura, Y, Kitamura, Y

Science 1998
11369651 Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells

Ning, ZQ, Li, J, Arceci, RJ

Blood 2001
17546049 KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway

Bauer, S, Duensing, A, Demetri, GD, Fletcher, JA

Oncogene 2007
15790786 Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412

Growney, JD, Clark, JJ, Adelsperger, J, Stone, R, Fabbro, D, Griffin, JD, Gilliland, DG

Blood 2005
Participants
Input
Output
Participates
as an event of
Normal reaction
JAK2 binds to p-KIT (Homo sapiens)
Functional status

Gain of function of KIT mutant dimers:SFKs [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2020-04-01)
Reviewed
Serrano, C  (2020-03-13)
García-Valverde, A  (2020-03-13)
Pilco-Janeta, D  (2020-03-13)
Created
Rothfels, K  (2019-12-09)
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