p-11Y PDGFRA V536E [plasma membrane]

Stable Identifier
R-HSA-9672018
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha platelet-derived growth factor receptor, PGDS_HUMAN
Icon
p-11Y PDGFRA V536E [plasma membrane] icon
p-11Y PDGFRA V536E [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
23752188 PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations

Velghe, AI, Van Cauwenberghe, S, Polyansky, AA, Chand, D, Montano-Almendras, CP, Charni, S, Hallberg, B, Essaghir, A, Demoulin, JB

Oncogene 2014
External Reference Information
External Reference
UniProt:P16234 PDGFRA
Gene Names
PDGFRA, PDGFR2, RHEPDGFRA
Chain
signal peptide:1-23, chain:24-1089
Reference Genes
BioGPS Gene:5156 PDGFRA
COSMIC (genes):PDGFRA PDGFRA
CTD Gene:5156 PDGFRA
dbSNP Gene:5156 PDGFRA
ENSEMBL:ENSG00000134853 PDGFRA
HGNC:8803 PDGFRA
KEGG Gene (Homo sapiens):5156 PDGFRA
Monarch:5156 PDGFRA
NCBI Gene:5156 PDGFRA
OMIM:173490 PDGFRA
UCSC:P16234 PDGFRA
Reference Transcript
Other Identifiers
0003190059
11743850_at
11750772_a_at
11760753_a_at
11762023_at
1554828_at
16966809
1731_at
1968_g_at
1987_at
203131_at
215305_at
2727350
2727370
2727372
2727373
2727374
2727375
2727376
2727377
2727378
2727380
2727381
2727382
2727383
2727386
2727387
2727388
2727389
2727391
2727393
2727395
2727396
2727397
2727398
2727401
2727402
2727403
2727404
2727406
2727407
2727408
2727411
2727413
2727414
2727415
5156
8095080
84284_at
A_14_P111616
A_14_P125923
A_23_P300033
A_23_P332536
GE57864
GO:0000003
GO:0000165
GO:0000166
GO:0001553
GO:0001701
GO:0001775
GO:0002244
GO:0002376
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005018
GO:0005021
GO:0005161
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005886
GO:0005887
GO:0005902
GO:0005929
GO:0006464
GO:0006468
GO:0006629
GO:0006935
GO:0006950
GO:0007010
GO:0007155
GO:0007165
GO:0007169
GO:0007204
GO:0007275
GO:0008150
GO:0008210
GO:0008283
GO:0008284
GO:0008585
GO:0009653
GO:0009790
GO:0009887
GO:0009897
GO:0009986
GO:0010544
GO:0010863
GO:0014068
GO:0016020
GO:0016021
GO:0016032
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0018108
GO:0019838
GO:0022607
GO:0023019
GO:0030054
GO:0030154
GO:0030198
GO:0030324
GO:0030325
GO:0030335
GO:0030539
GO:0031226
GO:0032991
GO:0033327
GO:0033674
GO:0034614
GO:0035790
GO:0038085
GO:0038091
GO:0040011
GO:0042060
GO:0042475
GO:0042592
GO:0042803
GO:0042995
GO:0043167
GO:0043226
GO:0043235
GO:0043552
GO:0044403
GO:0044877
GO:0046777
GO:0048008
GO:0048015
GO:0048146
GO:0048407
GO:0048557
GO:0048646
GO:0048701
GO:0048704
GO:0048705
GO:0048856
GO:0048870
GO:0050920
GO:0051897
GO:0055003
GO:0060021
GO:0060325
GO:0060326
GO:0061298
GO:0070374
GO:0070527
GO:0071230
GO:0072277
GO:2000249
GO:2000739
Hs.166074.0.S1_3p_at
Hs2.74615.2.A1_3p_at
Hs2.74615.2.A1_3p_s_at
ILMN_1681949
ILMN_2086470
M21574_at
PH_hs_0004257
TC04002931.hg
g5453869_3p_at
Participant Of
hasComponent
Other forms of this molecule
PDGFRA L629P [plasma membrane]
PDGFRA N659K [plasma membrane]
PDGFRA T674I [plasma membrane]
PDGFRA S601P [plasma membrane]
PDGFRA Y288C [endoplasmic reticulum membrane]
PDGFRA del375-455 [endoplasmic reticulum membrane]
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
p-11Y PDGFRA del375-455 [endoplasmic reticulum membrane]
PDGFRA D842_M844del [plasma membrane]
PDGFRA D842Y [plasma membrane]
PDGFRA D842V [plasma membrane]
PDGFRA D843_846del [plasma membrane]
PDGFRA D842_H845del [plasma membrane]
PDGFRA D842del [plasma membrane]
PDGFRA D842_I843delinsV [plasma membrane]
PDGFRA D846Y [plasma membrane]
PDGFRA D843_845del [plasma membrane]
PDGFRA D842_D846del [plasma membrane]
PDGFRA N848K [plasma membrane]
PDGFRA Y849C [plasma membrane]
PDGFRA D843_844del [plasma membrane]
PDGFRA D846V [plasma membrane]
PDGFRA D842L [plasma membrane]
PDGFRA V561D [plasma membrane]
PDGFRA V561A [plasma membrane]
PDGFRA V536E [plasma membrane]
PDGFRA V536M [plasma membrane]
p-11Y PDGFRA D842V [plasma membrane]
p-11Y PDGFRA D846Y [plasma membrane]
p-11Y PDGFRA D842del [plasma membrane]
p-11Y PDGFRA D843_844del [plasma membrane]
p-11Y PDGFRA D842_I843delinsV [plasma membrane]
p-11Y PDGFRA D843_846del [plasma membrane]
p-11Y PDGFRA D842Y [plasma membrane]
p-11Y PDGFRA D842_H845del [plasma membrane]
p-11Y PDGFRA D842_D846del [plasma membrane]
p-10Y PDGFRA Y849C [plasma membrane]
p-11Y PDGFRA D843_845del [plasma membrane]
p-11Y PDGFRA N848K [plasma membrane]
p-11Y PDGFRA D842L dimer [plasma membrane]
p-11Y PDGFRA D846V [plasma membrane]
p-11Y PDGFRA V536M [plasma membrane]
p-11Y PDGFRA V561D [plasma membrane]
p-11Y PDGFRA V561A [plasma membrane]
PDGFRA [plasma membrane]
p-11Y-PDGFRA [plasma membrane]
Modified Residues
Name
L-valine 536 replaced with L-glutamic acid
Coordinate
536
PsiMod
L-glutamic acid residue [MOD:00015]
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
L-valine removal [MOD:01650]
A protein modification that effectively removes or replaces an L-valine.
Name
O4'-phospho-L-tyrosine at 1018
Coordinate
1018
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 572
Coordinate
572
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 574
Coordinate
574
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 720
Coordinate
720
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 731
Coordinate
731
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 742
Coordinate
742
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 754
Coordinate
754
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 762
Coordinate
762
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 768
Coordinate
768
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 988
Coordinate
988
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 849
Coordinate
849
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
astrocytoma 3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
COSMIC
HPA
GeneCards
Ensembl
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (9)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01127 PDGFB  8 0.733 11
 UniProt:P46108 CRK  1 0.708 4
 UniProt:P04085 PDGFA  1 0.704 6
 UniProt:P00533 EGFR  59 0.683 4
 UniProt:P46109 CRKL  2 0.623 3
 UniProt:P09619 PDGFRB  3 0.564 2
 UniProt:Q8N6L0 KASH5      0.556 3
 UniProt:Q9NRA1 PDGFC      0.544 2
 UniProt:P19174 PLCG1  6 0.508 2
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