STAT binds to p-11Y PDGFRA extracellular domain dimers

Stable Identifier
R-HSA-9672159
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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STAT signaling is activated downstream of the PDGFRA Y288C extracellular domain mutant, similar to the wild-type receptor (Ip et al, 2018).
Literature References
PubMed ID Title Journal Year
30389923 Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Vellano, CP, Scott, KL, Ju, Z, Jeong, KJ, Shao, SH, Leonard, PG, Woessner, R, Mills, GB, Sahni, N, Ip, CKM, Hua, X, Ng, PKS

Nat Commun 2018
Participants
Participates
Functional status

Gain of function of extracellular domain mutant PDGFRA dimers [endoplasmic reticulum membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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