FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]

Stable Identifier
R-HSA-9672502
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
12660384 A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

Cools, J, Deangelo, DJ, Gotlib, J, Stover, EH, Legare, RD, Cortes, J, Kutok, J, Clark, J, Galinsky, I, Griffin, JD, Cross, NC, Tefferi, A, Malone, J, Alam, R, Schrier, SL, Schmid, J, Rose, M, Vandenberghe, P, Verhoef, G, Boogaerts, M, Wlodarska, I, Kantarjian, H, Marynen, P, Coutré, SE, Stone, R, Gilliland, DG

N. Engl. J. Med. 2003
External Reference Information
External Reference
UniProt:Q6UN15 FIP1L1
Gene Names
FIP1L1, FIP1, RHE
Chain
chain:1-594
Reference Genes
BioGPS Gene:81608 FIP1L1
COSMIC (genes):FIP1L1 FIP1L1
CTD Gene:81608 FIP1L1
dbSNP Gene:81608 FIP1L1
ENSEMBL:ENSG00000145216 FIP1L1
HGNC:19124 FIP1L1
KEGG:hsa:81608 FIP1L1
Monarch:81608 FIP1L1
NCBI Gene:81608 FIP1L1
OMIM:607686 FIP1L1
UCSC:Q6UN15 FIP1L1
Reference Transcript
Participates
as a component of
as a member of
Other forms of this molecule
FIP1L1 [nucleoplasm]
FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]
FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol]
FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]
p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]
p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]
p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]
p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol]
Modified Residues
Name
Replacement of residues 391 to 391 by PAQCP
Name
Insertion of residues 577 to 1089 at 392 from UniProt:P16234 PDGFRA
Coordinate
392
Disease
Name Identifier Synonyms
hypereosinophilic syndrome DOID:999 Eosinophilic leukocytosis, eosinophilia
Cross References
RefSeq
OpenTargets
ENSEMBL
Mondo
HPA
GeneCards
PRO
Pharos - Targets
GlyGen
Orphanet
PDB
Interactors (15)
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