FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]

Stable Identifier
R-HSA-9672506
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15070659 The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management

Gotlib, J, Cools, J, Malone, JM, Schrier, SL, Gilliland, DG, Coutré, SE

Blood 2004
12660384 A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

Cools, J, Deangelo, DJ, Gotlib, J, Stover, EH, Legare, RD, Cortes, J, Kutok, J, Clark, J, Galinsky, I, Griffin, JD, Cross, NC, Tefferi, A, Malone, J, Alam, R, Schrier, SL, Schmid, J, Rose, M, Vandenberghe, P, Verhoef, G, Boogaerts, M, Wlodarska, I, Kantarjian, H, Marynen, P, Coutré, SE, Stone, R, Gilliland, DG

N. Engl. J. Med. 2003
Participates
Other forms of this molecule
Modified Residues
Name
Replacement of residues 392 to 392 by GDCY
Name
Insertion of residues 585 to 1089 at 393 from UniProt:P16234 PDGFRA
Coordinate
393
Disease
Name Identifier Synonyms
hypereosinophilic syndrome DOID:999 Eosinophilic leukocytosis, eosinophilia
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