Reactome | PM20D1 hydrolyzes oleoyl-phe

PM20D1 hydrolyzes oleoyl-phe

Stable Identifier

R-HSA-9673054

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Extracellular PM20D1 (N-fatty-acyl-amino acid synthase/hydrolase PM20D1) catalyzes the reversible hydrolysis of oleoyl-phe (N-(9Z-octadecenoyl)-L-phenylalanine) to form L-phenylalanine (L-phe) and oleate ((9Z)-octadecenoate). In addition to the hydrolysis of oleoyl-phe (N-(9Z-octadecenoyl)-L-phenylalanine) annotated here, purified PM20D1 can hydrolyze a variety of n-acyl amino acids (Long et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
27374330	The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria Jedrychowski, MP, Spiegelman, BM, Gygi, SP, Lokurkar, IA, Lin, H, Svensson, KJ, Kamenecka, T, Paulo, JA, Rao, RR, Lou, J, Nomura, DK, Chang, MR, Long, JZ, Griffin, PR, Bateman, LA	Cell	2016