Reactome | PDGFRA Y375_K455del [endoplasmic reticulum membrane]

Name	Identifier	Synonyms
glioblastoma multiforme	DOID:3068	GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme

Cross References

RefSeq

XP_005265800.1, NP_006197.1, NP_001334758.1

Guide to Pharmacology - Targets

1803

OpenTargets

ENSG00000134853

ENSEMBL

ENST00000257290, ENSP00000425648, ENST00000508170, ENSP00000257290, ENST00000509490, ENSG00000134853, ENSP00000424218

ZINC - FDA approved

PGFRA_HUMAN

ZINC - Substances

PGFRA_HUMAN

ZINC - Biogenic

PGFRA_HUMAN

ZINC target

P16234

PRO

P16234

GlyGen

P16234

PDB

1GQ5, 5K5X, 7LBF, 6A32, 7RAM, 8PQI, 8PQK, 8PQH, 8PQJ, 6JOI, 5GRN, 6JOJ, 6JOK, 6JOL

ZINC - Investigational

PGFRA_HUMAN

GeneCards

PDGFRA

HPA

ENSG00000134853-PDGFRA

Pharos - Targets

P16234

Orphanet

PDGFRA

ZINC - Predictions - Purchasable

PGFRA_HUMAN

HMDB Protein

HMDBP01355

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01127 PDGFB	8	PDGFB (82-190) [extracellular region] (R-HSA-184201) PDGFB(82-241) [extracellular region] (R-HSA-381904) PDGFB(1-241) [endoplasmic reticulum lumen] (R-HSA-381903) PDGFB(1-241) [Golgi membrane] (R-HSA-380740) PDGFB(1-81) [Golgi lumen] (R-HSA-389058) PDGFB(191-241) [Golgi lumen] (R-HSA-396945) PDGFB(21-81) [platelet alpha granule lumen] (R-HSA-184200) PDGFB(82-241) [platelet alpha granule lumen] (R-HSA-387075)	0.733	11
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.706	5
UniProt:P04085 PDGFA	1	PDGFA [extracellular region] (R-HSA-2426265)	0.691	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.683	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.671	4
UniProt:Q9NRA1 PDGFC			0.656	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.569	3
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.544	3
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.483	2

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