p-11Y FIP1L1(1-395):PDGFRA (585-1069) fusion [cytosol]

Stable Identifier
R-HSA-9673621
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
12660384 A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

Cools, J, Deangelo, DJ, Gotlib, J, Stover, EH, Legare, RD, Cortes, J, Kutok, J, Clark, J, Galinsky, I, Griffin, JD, Cross, NC, Tefferi, A, Malone, J, Alam, R, Schrier, SL, Schmid, J, Rose, M, Vandenberghe, P, Verhoef, G, Boogaerts, M, Wlodarska, I, Kantarjian, H, Marynen, P, Coutré, SE, Stone, R, Gilliland, DG

N. Engl. J. Med. 2003
15070659 The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management

Gotlib, J, Cools, J, Malone, JM, Schrier, SL, Gilliland, DG, Coutré, SE

Blood 2004
External Reference Information
External Reference
Gene Names
FIP1L1, FIP1, RHE
Chain
chain:1-594
Other Identifiers
0006980204
11743936_a_at
11751233_a_at
11759532_at
11759533_s_at
1554424_at
16966748
221007_s_at
2727227
2727228
2727229
2727232
2727234
2727235
2727236
2727238
2727239
2727240
2727242
2727244
2727245
2727246
2727249
2727252
2727253
2727258
2727263
2727265
2727268
2727269
2727274
2727275
2727276
2727277
2727278
2727279
37475
43072_s_at
58202
58459_s_at
8095048
81608
A_23_P58337
A_24_P20623
A_24_P265162
AAH11543
AAH17724
AAH24016
AAH52959
AAI10384
AAP69563
AAQ88277
AC058822
AC095040
AC098587
AC098821
AC105384
AC110298
AC110792
AC124017
AC138607
AC138779
AK295737
AL136910
AY229892
AY366510
BAG58575
BC011543
BC017724
BC024016
BC052959
BC110383
CAB66844
CCDS3491
CCDS47055
CCDS47056
CH471057
EAX05448
ENSG00000145216
ENSP00000302993
ENSP00000336752
ENSP00000351383
ENSP00000425456
ENST00000306932
ENST00000306932.10
ENST00000337488
ENST00000337488.10
ENST00000358575
ENST00000358575.9
ENST00000507922
ENST00000507922.5
EntrezGene:81608
EntrezGene:FIP1L1
FIP1L1
FIP1L1-201
FIP1L1-202
FIP1L1-203
FIP1L1-207
g13569873_3p_s_at
GE83194
GO:0000398
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005847
GO:0006369
GO:0006378
GO:0006397
GO:0006406
GO:0006810
GO:0006913
GO:0008150
GO:0009058
GO:0015031
GO:0031124
GO:0032991
GO:0034641
GO:0043226
GO:0098789
H0Y8P7
HGNC:19124
HPA037475
HPA058202
Hs.66295.2.A1_3p_at
Hs2.334812.2.S1_3p_s_at
ILMN_1768743
ILMN_2190942
IPR007854
IPR039849
MIM:607686
NM_001134937
NM_001134938
NM_030917
NP_001128409
NP_001128410
NP_112179
PF05182
PH_hs_0016478
TC04002930.hg
UPI0000035FBF
UPI0000037BDE
UPI000006F530
UPI0000D9B14D
XM_005265769
XM_005265773
XM_005265774
XM_005265778
XM_005265779
XM_005265781
XM_005265782
XM_017008662
XM_017008663
XM_017008664
XM_017008665
XM_017008666
XM_017008667
XM_017008668
XM_017008669
XM_017008670
XM_017008671
XP_005265826
XP_005265830
XP_005265831
XP_005265835
XP_005265836
XP_005265838
XP_005265839
XP_016864151
XP_016864152
XP_016864153
XP_016864154
XP_016864155
XP_016864156
XP_016864157
XP_016864158
XP_016864159
XP_016864160
Participant Of
Other forms of this molecule
Modified Residues
Name
Replacement of residues 392 to 395 by GDCY
Name
Insertion of residues 585 to 1069 at 396 from UniProt:P16234 PDGFRA
Coordinate
396
Name
O4'-phospho-L-tyrosine at 1018
Coordinate
1018
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 572
Coordinate
572
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 574
Coordinate
574
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 720
Coordinate
720
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 731
Coordinate
731
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 742
Coordinate
742
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 754
Coordinate
754
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 762
Coordinate
762
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 768
Coordinate
768
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 988
Coordinate
988
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 849
Coordinate
849
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
hypereosinophilic syndrome 999 Eosinophilic leukocytosis, eosinophilia
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