p-11Y PDGFRA D846V [plasma membrane]

Stable Identifier
R-HSA-9674316
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha platelet-derived growth factor receptor, PGDS_HUMAN
Icon
p-11Y PDGFRA D846V [plasma membrane] icon
p-11Y PDGFRA D846V [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
30318721 Prolonged response to sorafenib in a patient with refractory metastatic osteosarcoma and a somatic PDGFRA D846V mutation

Armstrong, AE, Reichek, J, Leavey, PJ, Walterhouse, DO, Walz, AL

Pediatr Blood Cancer 2019
External Reference Information
External Reference
UniProt:P16234 PDGFRA
Gene Names
PDGFRA, PDGFR2, RHEPDGFRA
Chain
signal peptide:1-23, chain:24-1089
Reference Genes
BioGPS Gene:5156 PDGFRA
COSMIC (genes):PDGFRA PDGFRA
CTD Gene:5156 PDGFRA
dbSNP Gene:5156 PDGFRA
ENSEMBL:ENSG00000134853 PDGFRA
HGNC:8803 PDGFRA
KEGG:hsa:5156 PDGFRA
Monarch:5156 PDGFRA
NCBI Gene:5156 PDGFRA
OMIM:173490 PDGFRA
UCSC:P16234 PDGFRA
Reference Transcript
Participates
as a component of
Other forms of this molecule
PDGFRA L629P [plasma membrane]
PDGFRA N659K [plasma membrane]
PDGFRA T674I [plasma membrane]
PDGFRA S601P [plasma membrane]
PDGFRA Y288C [endoplasmic reticulum membrane]
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
PDGFRA D842_M844del [plasma membrane]
PDGFRA D842Y [plasma membrane]
PDGFRA D842V [plasma membrane]
PDGFRA I843_D846del [plasma membrane]
PDGFRA D842_H845del [plasma membrane]
PDGFRA D842del [plasma membrane]
PDGFRA D842_I843delinsV [plasma membrane]
PDGFRA D846Y [plasma membrane]
PDGFRA D843_845del [plasma membrane]
PDGFRA D842_D846del [plasma membrane]
PDGFRA N848K [plasma membrane]
PDGFRA Y849C [plasma membrane]
PDGFRA D843_844del [plasma membrane]
PDGFRA D846V [plasma membrane]
PDGFRA D842L [plasma membrane]
PDGFRA V561D [plasma membrane]
PDGFRA V561A [plasma membrane]
PDGFRA V536E [plasma membrane]
PDGFRA V536M [plasma membrane]
p-11Y PDGFRA D842V [plasma membrane]
p-11Y PDGFRA D846Y [plasma membrane]
p-11Y-PDGFRA [plasma membrane]
PDGFRA [plasma membrane]
p-11Y PDGFRA V561A [plasma membrane]
p-11Y PDGFRA V561D [plasma membrane]
p-11Y PDGFRA V536M [plasma membrane]
p-11Y PDGFRA V536E [plasma membrane]
p-11Y PDGFRA D842L dimer [plasma membrane]
p-11Y PDGFRA N848K [plasma membrane]
p-11Y PDGFRA D843_845del [plasma membrane]
p-10Y PDGFRA Y849C [plasma membrane]
p-11Y PDGFRA D842_D846del [plasma membrane]
p-11Y PDGFRA D842_H845del [plasma membrane]
p-11Y PDGFRA D842Y [plasma membrane]
p-11Y PDGFRA D843_846del [plasma membrane]
p-11Y-PDGFRA D842_I843delinsV [plasma membrane]
p-11Y PDGFRA D843_844del [plasma membrane]
p-11Y PDGFRA D842del [plasma membrane]
Modified Residues
Name
L-aspartic acid 846 replaced with L-valine
Coordinate
846
PsiMod
L-valine residue [MOD:00029]
A protein modification that effectively converts a source amino acid residue to an L-valine.
L-aspartic acid removal [MOD:01634]
A protein modification that effectively removes or replaces an L-aspartic acid.
Name
O4'-phospho-L-tyrosine at 1018
Coordinate
1018
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 572
Coordinate
572
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 574
Coordinate
574
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 720
Coordinate
720
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 731
Coordinate
731
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 742
Coordinate
742
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 754
Coordinate
754
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 762
Coordinate
762
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 768
Coordinate
768
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 988
Coordinate
988
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 849
Coordinate
849
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
gastrointestinal stromal tumor DOID:9253 GANT, GIST, Stromal tumor of gastrointestinal tract
osteosarcoma DOID:3347 osteoid sarcoma, Skeletal sarcoma, Osteogenic sarcoma, bone tissue neoplasm
lung squamous cell carcinoma DOID:3907 squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Investigational
COSMIC
GeneCards
HPA
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (10)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01127 PDGFB  8 0.733 11
 UniProt:P09619 PDGFRB  3 0.706 5
 UniProt:P04085 PDGFA  1 0.691 6
 UniProt:P00533 EGFR  20 0.683 4
 UniProt:P46108 CRK  1 0.671 4
 UniProt:Q9NRA1 PDGFC      0.656 3
 UniProt:P46109 CRKL  2 0.569 3
 UniProt:Q8N6L0 KASH5      0.556 3
 UniProt:P19174 PLCG1  6 0.544 3
 UniProt:Q8WVM8 SCFD1  1 0.483 2
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