Regorafenib-resistant PDGFR mutants don't bind regorafenib

Stable Identifier
R-HSA-9674408
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Regorafenib-resistant PDGFR mutants don't bind regorafenib
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Regorafenib only weakly inhibits the activity of the most prevalent PDGFRA mutation, D842V (Evans et al, 2017).

Literature References
PubMed ID Title Journal Year
29093181 A precision therapy against cancers driven by KIT/PDGFRA mutations

Evans, EK, Gardino, AK, Kim, JL, Hodous, BL, Shutes, A, Davis, A, Zhu, XJ, Schmidt-Kittler, O, Wilson, D, Wilson, K, DiPietro, L, Zhang, Y, Brooijmans, N, LaBranche, TP, Wozniak, A, Gebreyohannes, YK, Schöffski, P, Heinrich, MC, Deangelo, DJ, Miller, S, Wolf, B, Kohl, N, Guzi, T, Lydon, N, Boral, A, Lengauer, C

Sci Transl Med 2017
Participants
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Participant Of
hasEvent
Normal reaction
PDGFRs bind type II TKI (Homo sapiens)
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-02-25)
Reviewed
Ip, CKM  (2020-02-06)
Created
Rothfels, K  (2020-01-13)
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