Diseases of mitotic cell cycle

Stable Identifier
R-HSA-9675126
Type
Pathway
Species
Homo sapiens
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Diseases of mitotic cell cycle are caused by mutations in cell cycle regulators (Collins and Garrett 2005, Diaz-Moralli et al. 2013), such as retinoblastoma protein RB1 (Classon and Harlow 2002), as well as proteins involved in telomere maintenance, such as ATRX and DAXX (Sarek et al. 2015). These diseases mainly include different types of cancer, hereditary syndromes such as dyskeratosis congenita that may predispose affected patients to cancer, and neurodegenerative diseases (Webber et al. 2005).

Literature References
PubMed ID Title Journal Year
15964238 Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors

Collins, I, Garrett, MD

Curr Opin Pharmacol 2005
23356980 Targeting cell cycle regulation in cancer therapy

Diaz-Moralli, S, Tarrado-Castellarnau, M, Miranda, A, Cascante, M

Pharmacol. Ther. 2013
26581521 Molecular basis of telomere dysfunction in human genetic diseases

Sarek, G, Marzec, P, Margalef, P, Boulton, SJ

Nat. Struct. Mol. Biol. 2015
15936057 The cell cycle in Alzheimer disease: a unique target for neuropharmacology

Webber, KM, Raina, AK, Marlatt, MW, Zhu, X, Prat, MI, Morelli, L, Casadesus, G, Perry, G, Smith, MA

Mech. Ageing Dev. 2005
12459729 The retinoblastoma tumour suppressor in development and cancer

Classon, M, Harlow, E

Nat. Rev. Cancer 2002
Participants
Participant Of
hasEvent
Disease
Name Identifier Synonyms
disease of cellular proliferation 14566 neoplasm, cell process disease
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