Diseases of cellular response to stress

Stable Identifier
R-HSA-9675132
Type
Pathway
Species
Homo sapiens
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Cells are subject to external and internal stressors, such as foreign molecules that perturb metabolic or signaling processes, cellular respiration-generated reactive oxygen species that can cause DNA damage, oxygen and nutrient deprivation, and changes in temperature or pH. The ability of cells and tissues to respond to stress is essential to the maintenance of tissue homeostasis (Kultz 2005) and dysregulation of cellular response to stress is involved in disease.

So far, we have captured diseases of cellular senescence.

Impaired cellular senescence contributes to malignant transformation and cancer development by enabling continuous proliferation of damaged cells. On the other hand, presence of an excessive number of senescent cells that are not cleared by the immune system promotes tissue inflammation and creates a microenvironment suitable for growth of neighboring malignant cells. In addition to cancer, senescence is also involved in other age-related diseases such as atherosclerosis, osteoarthritis, chronic obstructive lung disease, and diabetes (Childs et al. 2015, He and Sharpless 2017, Hamsanathan et al. 2019, Faget et al. 2019, Gorgoulis et al. 2019, Rhinn et al. 2019). Senotherapy is a new field of pharmacology that aims to therapeutically target senescence to improve healthy aging and age-related diseases (Schmitt 2017, Gorgoulis et al. 2019).

Literature References
PubMed ID Title Journal Year
15709958 Molecular and evolutionary basis of the cellular stress response

K├╝ltz, D

Annu. Rev. Physiol. 2005
31575608 Cellular senescence in development, regeneration and disease

Rhinn, M, Ritschka, B, Keyes, WM

Development 2019
30965013 Cellular Senescence: The Trojan Horse in Chronic Lung Diseases

Hamsanathan, S, Alder, JK, Sellares, J, Rojas, M, Gurkar, AU, Mora, AL

Am. J. Respir. Cell Mol. Biol. 2019
31235879 Unmasking senescence: context-dependent effects of SASP in cancer

Faget, DV, Ren, Q, Stewart, SA

Nat. Rev. Cancer 2019
31675495 Cellular Senescence: Defining a Path Forward

Gorgoulis, V, Adams, PD, Alimonti, A, Bennett, DC, Bischof, O, Bishop, C, Campisi, J, Collado, M, Evangelou, K, Ferbeyre, G, Gil, J, Hara, E, Krizhanovsky, V, Jurk, D, Maier, AB, Narita, M, Niedernhofer, L, Passos, JF, Robbins, PD, Schmitt, CA, Sedivy, J, Vougas, K, von Zglinicki, T, Zhou, D, Serrano, M, Demaria, M

Cell 2019
28575665 Senescence in Health and Disease

He, S, Sharpless, NE

Cell 2017
26646499 Cellular senescence in aging and age-related disease: from mechanisms to therapy

Childs, BG, Durik, M, Baker, DJ, van Deursen, JM

Nat. Med. 2015
28389776 Senotherapy: growing old and staying young?

Schmitt, R

Pflugers Arch. 2017
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disease 4
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