Reactome | p-Y643-GAB2 [cytosol]

p-Y643-GAB2 [cytosol]

Stable Identifier

R-HSA-9677149

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GRB2-associated-binding protein 2, GAB2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UQC2 GAB2

Gene Names

GAB2, KIAA0571

Chain

chain:1-676

Reference Genes

BioGPS Gene:9846 GAB2

COSMIC (genes):GAB2 GAB2

CTD Gene:9846 GAB2

dbSNP Gene:9846 GAB2

ENSEMBL:ENSG00000033327 GAB2

HGNC:14458 GAB2

KEGG:hsa:9846 GAB2

Monarch:9846 GAB2

NCBI Gene:9846 GAB2

OMIM:606203 GAB2

UCSC:Q9UQC2 GAB2

Reference Transcript

Participates

as a component of

CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y-GAB2 [cytosol]

p-Y452,Y476,Y584-GAB2 [cytosol]

GAB2 [cytosol]

p-5Y-GAB2 [cytosol]

Inferred To

phospho-Gab2 [cytosol] (Mus musculus)

phospho-Gab2 [cytosol] (Rattus norvegicus)

phospho-GAB2 [cytosol] (Bos taurus)

phospho-GAB2 [cytosol] (Canis familiaris)

phospho-GAB2 [cytosol] (Sus scrofa)

phospho-dos [cytosol] (Drosophila melanogaster)

phospho-p-Y643-GAB2 [cytosol] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 643

Coordinate

643

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_006718816.1, NP_536739.1, NP_036428.1

OpenTargets

ENSG00000033327

ENSEMBL

ENST00000361507, ENSP00000343959, ENSP00000354952, ENSG00000033327, ENST00000340149

HPA

ENSG00000033327-GAB2

GeneCards

GAB2

PRO

Q9UQC2

Pharos - Targets

Q9UQC2

PDB

6Y3S, 6Y3R, 6ZVC, 6ZVB, 5EWZ, 5EXA, 2VWF, 6ZVE, 6ZVD, 2W0Z

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.953	16
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.839	8
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.827	7
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.802	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.774	7
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.727	7
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.706	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.669	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.666	5
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.643	4
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.615	6
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.564	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P08865 RPSA	2	RPSA [cytosol] (R-HSA-72389) RPSA [nucleoplasm] (R-HSA-6798722)	0.556	3
UniProt:P11117 PPAL			0.556	3
UniProt:Q96JP2 MY15B			0.556	3
UniProt:Q8WZ73-3 Q8WZ733			0.556	3
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.544	2

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