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p-Y643-GAB2 [cytosol]
Stable Identifier
R-HSA-9677149
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GRB2-associated-binding protein 2, GAB2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
p-Y643-GAB2 [cytosol] (Homo sapiens)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
p-Y643-GAB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQC2 GAB2
Gene Names
GAB2, KIAA0571
Chain
chain:1-676
Reference Genes
BioGPS Gene:9846 GAB2
COSMIC (genes):GAB2 GAB2
CTD Gene:9846 GAB2
dbSNP Gene:9846 GAB2
ENSEMBL:ENSG00000033327 GAB2
ENSEMBL:ENSG00000033327.13 GAB2
HGNC:14458 GAB2
KEGG Gene (Homo sapiens):9846 GAB2
Monarch:9846 GAB2
NCBI Gene:9846 GAB2
OMIM:606203 GAB2
UCSC:Q9UQC2 GAB2
Reference Transcript
RefSeq:NM_080491.2 GAB2
RefSeq:XM_006718753.2 GAB2
RefSeq:NM_012296.3 GAB2
Other Identifiers
11724867_a_at
11737624_a_at
16742647
203853_PM_s_at
203853_s_at
3383228
3383229
3383230
3383231
3383232
3383233
3383234
3383235
3383236
3383237
3383238
3383239
3383243
3383244
3383258
3383259
3383278
3383295
3383296
35253_at
7950671
9846
A_23_P203743
A_24_P98843
GE53283
GO:0002376
GO:0005068
GO:0005515
GO:0005547
GO:0005737
GO:0005829
GO:0005886
GO:0007165
GO:0007169
GO:0008284
GO:0008289
GO:0016020
GO:0016192
GO:0023052
GO:0030154
GO:0030316
GO:0043306
GO:0043325
GO:0048015
GO:0048856
GO:0060090
HMNXSV003056815
ILMN_1665964
ILMN_1728746
ILMN_1815758
PH_hs_0002620
TC11002136.hg
g6912459_3p_a_at
Participates
as a component of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-5Y-GAB2 [cytosol]
p-Y-GAB2 [cytosol]
p-Y452,Y476,Y584-GAB2 [cytosol]
GAB2 [cytosol]
Inferred To
phospho-Gab2 [cytosol]
(Mus musculus)
phospho-Gab2 [cytosol]
(Rattus norvegicus)
phospho-GAB2 [cytosol]
(Bos taurus)
phospho-GAB2 [cytosol]
(Sus scrofa)
phospho-p-Y643-GAB2 [cytosol]
(Canis familiaris)
phospho-p-Y643-GAB2 [cytosol]
(Danio rerio)
phospho-p-Y643-GAB2 [cytosol]
(Gallus gallus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 643
Coordinate
643
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_536739.1
,
NP_036428.1
,
XP_006718816.1
OpenTargets
ENSG00000033327
GeneCards
Q9UQC2
HPA
ENSG00000033327-GAB2
Ensembl
ENST00000361507
,
ENSP00000343959
,
ENSG00000033327
,
ENST00000340149
,
ENSP00000354952
PRO
Q9UQC2
Pharos - Targets
Q9UQC2
Orphanet
28320
PDB
6ZVE
,
6ZVB
,
5EXA
,
6Y3R
,
2W0Z
,
6ZVC
,
2VWF
,
5EWZ
,
6Y3S
,
6ZVD
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.95
15
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.669
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.643
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.643
4
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.643
4
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.643
4
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.564
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.558
4
UniProt:Q8WZ73-3 Q8WZ733
0.556
3
UniProt:P11117 PPAL
0.556
3
UniProt:A0A024R8L2 A0A024R8L2
0.556
3
UniProt:P08865 RPSA
2
RPSA [nucleoplasm]
(R-HSA-6798722)
RPSA [cytosol]
(R-HSA-72389)
0.556
3
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P29353 SHC1
5
SHC1 [cytosol]
(R-HSA-74680)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
0.544
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.527
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.527
3
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