Reactome | PLEKHG4 [cytosol]

PLEKHG4 [cytosol]

Stable Identifier

R-HSA-9679579

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Puratrophin-1 alternativeName: Pleckstrin homology domain-containing family G member 4, PRTPHN1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q58EX7 PLEKHG4

Gene Names

PLEKHG4, PRTPHN1

Chain

chain:1-1191

Reference Genes

BioGPS Gene:25894 Q58EX72

COSMIC (genes):PLEKHG4 PLEKHG4

CTD Gene:25894 Q58EX72

dbSNP Gene:25894 Q58EX72

ENSEMBL:ENSG00000196155 PLEKHG4

HGNC:24501 Q58EX72

KEGG:hsa:25894 Q58EX72

Monarch:25894 Q58EX72

NCBI Gene:25894 Q58EX72

OMIM:609526 Q58EX72

UCSC:Q58EX7 Q58EX72

Reference Transcript

Participates

as a candidate of

as a member of

CDC42 GEFs [cytosol] (Homo sapiens)

Inferred To

Dmel\CG15611 [cytosol] (Drosophila melanogaster)

Homologues of PLEKHG4 [cytosol] (Drosophila melanogaster)

CG15612 [cytosol] (Drosophila melanogaster)

trio [cytosol] (Drosophila melanogaster)

Arhgef25 [cytosol] (Mus musculus)

Arhgef25 [cytosol] (Rattus norvegicus)

ARHGEF25 [cytosol] (Bos taurus)

ARHGEF25 [cytosol] (Canis familiaris)

ARHGEF25 [cytosol] (Sus scrofa)

unc-73 [cytosol] (Caenorhabditis elegans)

arhgef25 [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000196155

ENSEMBL

ENST00000427155, ENSP00000353646, ENSP00000398030, ENSP00000457086, ENST00000563969, ENSP00000401118, ENST00000379344, ENST00000393966, ENST00000450733, ENSG00000196155, ENSP00000368649, ENSP00000462601, ENST00000360461

HPA

ENSG00000196155-PLEKHG4

GeneCards

PLEKHG4

PRO

Q58EX7

Pharos - Targets

Q58EX7

Orphanet

PLEKHG4

GlyGen

Q58EX7

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3
UniProt:Q15475 SIX1	1	SIX1 [nucleoplasm] (R-HSA-9757860)	0.556	3
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q99633 PRPF18	1	PRPF18 [nucleoplasm] (R-HSA-5688093)	0.556	3
UniProt:Q9NQ94 A1CF	1	A1CF [nucleoplasm] (R-HSA-3211440)	0.556	3
UniProt:Q6W0C5 DPPA3	2	DPPA3 [cytosol] (R-HSA-9818458) DPPA3 [nucleoplasm] (R-HSA-9817479)	0.556	3
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [secretory granule lumen] (R-HSA-6803287)	0.556	3

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