Reactome | SIGMAR1 [cytosol]

SIGMAR1 [cytosol]

Stable Identifier

R-HSA-9679757

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sigma non-opioid intracellular receptor 1, SGMR1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99720 SIGMAR1

Gene Names

SIGMAR1, OPRS1, SRBP, AAG8

Chain

chain:1-223

Reference Genes

BioGPS Gene:10280 SIGMAR1

COSMIC (genes):SIGMAR1 SIGMAR1

CTD Gene:10280 SIGMAR1

dbSNP Gene:10280 SIGMAR1

ENSEMBL:ENSG00000147955 SIGMAR1

HGNC:8157 SIGMAR1

KEGG:hsa:10280 SIGMAR1

Monarch:10280 SIGMAR1

NCBI Gene:10280 SIGMAR1

OMIM:601978 SIGMAR1

UCSC:Q99720 SIGMAR1

Reference Transcript

Participates

as a component of

as an input of

Cross References

Guide to Pharmacology - Targets

2552

OpenTargets

ENSG00000147955

ENSEMBL

ENSG00000147955, ENSP00000420022, ENST00000277010, ENST00000679597, ENST00000477726, ENSP00000434453, ENSP00000277010, ENSP00000505634, ENST00000353468

ZINC - FDA approved

SGMR1_HUMAN

ZINC - Substances

SGMR1_HUMAN

ZINC - Biogenic

SGMR1_HUMAN

ZINC target

Q99720

PRO

Q99720

PDB

6DK0, 6DK1, 5HK1, 5HK2, 6DJZ

ZINC - Investigational

SGMR1_HUMAN

ZINC - Metabolites

SGMR1_HUMAN

HPA

ENSG00000147955-SIGMAR1

GeneCards

SIGMAR1

Pharos - Targets

Q99720

ZINC - Predictions - Purchasable

SGMR1_HUMAN

HMDB Protein

HMDBP07857

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449624 REP			0.788	5
UniProt:P14416 DRD2	1	DRD2 [plasma membrane] (R-HSA-390816)	0.518	5
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [azurophil granule membrane] (R-HSA-6800997)	0.508	2
UniProt:Q92847-1 GHSR			0.505	8
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.462	3

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