Signaling by extracellular domain mutants of KIT

Stable Identifier
R-HSA-9680187
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signaling by extracellular domain mutants of KIT
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Many of the described KIT mutations are located in the fifth Ig-like domain, encoded by exon 8 and 9. The fifth Ig-like domain of KIT plays a critical role in stabilizing the receptor dimers formed upon SCF binding, allowing these mutations to support constitutive activation of the receptor (Yuzawa et al, 2007; reviewed in Lennartsson and Ronnstrand, 2012)
Literature References
PubMed ID Title Journal Year
23073628 Stem cell factor receptor/c-Kit: from basic science to clinical implications

Lennartsson, J, Rönnstrand, L

Physiol. Rev. 2012
17662946 Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor

Yuzawa, S, Opatowsky, Y, Zhang, Z, Mandiyan, V, Lax, I, Schlessinger, J

Cell 2007
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2020-03-24)
Reviewed
Serrano, C  (2020-03-13)
Pilco-Janeta, D  (2020-03-13)
García-Valverde, A  (2020-03-13)
Created
Rothfels, K  (2020-03-25)
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