nsp15 binds RB1

Stable Identifier
R-HSA-9682712
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
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General
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Human SARS coronavirus 1 (SARS-CoV-1) non-structural protein 15 (nsp15) contains the LXCXE/D motif characteristic of proteins that bind to the retinoblastoma protein RB1. Binding to human RB1 increases the endonuclease activity of nsp15 but is not required for it. RB1 bound to nsp15 is retained in the cytosol. Interaction of nsp15 with RB1 likely affects the cell cycle of infected cells and probably modulates cytotoxicity of SARS-CoV-1 (Bhardwaj et al. 2012).

Literature References
PubMed ID Title Journal Year
22301153 The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein

Bhardwaj, K, Liu, P, Leibowitz, JL, Kao, CC

J. Virol. 2012
Participants
Participant Of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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