CQ, HCQ diffuses from cytosol to endocytic vesicle lumen

Stable Identifier
R-HSA-9683478
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endocytic vesicle lumen
ReviewStatus
5/5
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CQ, HCQ diffuses from cytosol to endocytic vesicle lumen
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Unprotonated chloroquine (CQ) and hydroxychloroquine (HCQ) can both diffuse freely and rapidly across the membranes of cells and organelles (Chinappi et al. 2010).
Literature References
PubMed ID Title Journal Year
21124966 On the mechanism of chloroquine resistance in Plasmodium falciparum

Marcatili, P, Chinappi, M, Via, A, Tramontano, A

PLoS ONE 2010
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Authored
Gillespie, ME  (2020-09-09)
Reviewed
Acencio, ML  (2020-09-09)
Created
Jassal, B  (2020-04-16)
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