Reactome | glycosylated-ACE2 [plasma membrane]

glycosylated-ACE2 [plasma membrane]

Stable Identifier

R-HSA-9683480

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Angiotensin-converting enzyme 2, ACE2_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
14754895	ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis Williams, D, Pantoliano, MW, Menon, S, Patane, MA, Fisher, M, Ryan, D, Towler, P, Dales, NA, Prasad, SG, Tang, J, Staker, B, Parsons, T	J. Biol. Chem.	2004

External Reference Information

External Reference

UniProt:Q9BYF1 ACE2

Gene Names

ACE2, UNQ868/PRO1885

Chain

signal peptide:1-17, chain:18-805, chain:18-708

Reference Genes

BioGPS Gene:59272 ACE2

COSMIC (genes):ACE2 ACE2

CTD Gene:59272 ACE2

dbSNP Gene:59272 ACE2

ENSEMBL:ENSG00000130234.13 ACE2

HGNC:13557 ACE2

KEGG Gene (Homo sapiens):59272 ACE2

Monarch:59272 ACE2

NCBI Gene:59272 ACE2

OMIM:300335 ACE2

UCSC:Q9BYF1 ACE2

Reference Transcript

RefSeq:NM_021804.2 ACE2

Other Identifiers

0006590519

11725624_at

11725625_s_at

11725626_a_at

17109301

219962_PM_at

219962_at

222257_PM_s_at

222257_s_at

242967_PM_at

242967_at

4000604

4000606

4000607

4000608

4000609

4000611

4000612

4000615

4000616

4000617

4000618

4000619

4000621

4000623

4000624

4000625

4000626

4000627

4000628

4000629

4000630

4000631

4000632

4000633

4000634

4000635

4000636

4000637

4000638

4000640

51620_at

54498_at

59272

8171449

A_23_P252981

GE56434

GO:0001618

GO:0001817

GO:0002003

GO:0003012

GO:0003013

GO:0003051

GO:0003081

GO:0004175

GO:0004180

GO:0004181

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005886

GO:0005929

GO:0006508

GO:0006954

GO:0008233

GO:0008237

GO:0008241

GO:0008270

GO:0009986

GO:0015827

GO:0016020

GO:0016021

GO:0016192

GO:0016324

GO:0016787

GO:0019058

GO:0019065

GO:0019229

GO:0022414

GO:0022898

GO:0023052

GO:0030666

GO:0031410

GO:0031526

GO:0034330

GO:0042127

GO:0042802

GO:0042995

GO:0043226

GO:0045121

GO:0046718

GO:0046813

GO:0046872

GO:0048662

GO:0050727

GO:0050877

GO:0050886

GO:0051604

GO:0051957

GO:0055085

GO:0060135

GO:0060452

GO:0061024

GO:0061025

GO:0070062

GO:0070373

GO:0097746

GO:0110165

GO:0140096

GO:1903598

GO:1903779

GO:1905737

GO:2000272

GO:2000379

HMNXSV003041042

Hs.290585.0.A1_3p_s_at

Hs.299056.0.A1_3p_at

ILMN_1667018

PH_hs_0010582

TC0X000878.hg

g11225608_3p_a_at

Participates

as a component of

as an input of

as an output of

Other forms of this molecule

ACE2(18-805) [plasma membrane]

ACE2 [endoplasmic reticulum lumen]

glycosylated-ACE2 [endocytic vesicle membrane]

ACE2 [endocytic vesicle membrane]

Modified Residues

Name

N4-glycosyl-L-asparagine at 53

Coordinate

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Name

N4-glycosyl-L-asparagine at 90

Coordinate

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Name

N4-glycosyl-L-asparagine at 103

Coordinate

103

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Name

N4-glycosyl-L-asparagine at 322

Coordinate

322

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Name

N4-glycosyl-L-asparagine at 432

Coordinate

432

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Name

N4-glycosyl-L-asparagine at 546

Coordinate

546

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Cross References

RefSeq

NP_068576.1

Guide to Pharmacology - Targets

1614

OpenTargets

ENSG00000130234

ZINC - Substances

ACE2_HUMAN

ZINC target

Q9BYF1

PRO

Q9BYF1

PDB

7SXX, 7V86, 7WPC, 7A97, 7V81, 7TEW, 6CS2, 7V83, 7DX5, 7SXZ, 6M17, 7SXY, 7V82, 3D0G, 7VXD, 7E7E, 7DX6, 7W9I, 7W98, 7DQA, 7VX9, 7TEX, 7DX7, 6M1D, 1R42, 6ACK, 7W99, 7PKI, 7DX8, 7EKC, 7NXC, 7FDI, 7VXC, 7DDP, 7W9B, 7DDO, 7DX9, 7SY4, 7R1A, 7SY3, 7KJ2, 7EKE, 3D0I, 7JVO, 7U0N, 7VXF, 7SY5, 3KBH, 7SY0, 7DF4, 7W9C, 7KMB, 7EKF, 7FDG, 7A95, 7WPB, 7R10, 7VX4, 7V87, 7WBL, 3SCJ, 7SY6, 6VW1, 7WBQ, 7SY1, 7R11, 7EKG, 7KJ4, 7FEM, 7RPV, 7A92, 7VX5, 7BH9, 7WBP, 7WPA, 7R12, 7V8A, 7WK4, 7SY7, 7TEZ, 7VXM, 7TF0, 7T9L, 7EDJ, 6ACG, 3SCL, 7SY8, 7T9K, 7A98, 7R0Z, 7KNB, 7WK5, 7V88, 7KJ3, 7A96, 1R4L, 7WK6, 7VXK, 6M0J, 3SCI, 7EFR, 7KNE, 7DRV, 7LO4, 7WVQ, 7FDH, 7EKH, 7V80, 7KNH, 7VXA, 6ACJ, 7KNI, 7CT5, 7KMS, 7WVP, 7SY2, 7MJM, 7MJN, 7DWX, 7DX4, 7KMZ, 7VXB, 7L7F, 6M18, 7EFP, 3D0H, 6LZG, 7DMU, 2AJF, 3SCK, 7A94, 7SN0, 7V84, 7V89, 7L0N, 7A91, 7TN0, 7V8B, 7V85, 7V7Z

ZINC - Investigational

ACE2_HUMAN

HPA

ENSG00000130234-ACE2

GeneCards

Q9BYF1

Ensembl

ENST00000677282, ENST00000252519, ENSP00000504103, ENSP00000389326, ENSG00000130234, ENST00000680121, ENSP00000504747, ENSP00000252519, ENSP00000505992, ENST00000427411, ENST00000678073

Pharos - Targets

Q9BYF1

ZINC - Predictions - Purchasable

ACE2_HUMAN

HMDB Protein

HMDBP08177

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.998	254
UniProt:P59594 S	12	nascent Spike [endoplasmic reticulum lumen] (R-COV-9682868) N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683594) trimmed unfolded N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683716) trimmed N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683608) trimmed N-glycan-PALM-Spike [endoplasmic reticulum lumen] (R-COV-9683638) trimmed N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683657) complex N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683617) complex N-glycan-PALM-Spike [virion membrane] (R-COV-9685469) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9686730) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9686693) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9686706) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9686724)	0.988	57
UniProt:Q6Q1S2 SPIKE			0.862	9
UniProt:Q9BYF1 ACE2	5	ACE2(18-805) [plasma membrane] (R-HSA-2022344) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480)	0.844	8
UniProt:P01042-PRO_0000006688 KNG1			0.73	5
IntAct:EBI-25504301 PEPTIDE-MCA-YVADAPK-DNP			0.73	16
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.722	6
UniProt:P59594-PRO_0000037209 S			0.713	3
UniProt:Q5T2W1 NHRF3			0.713	3
UniProt:P52293 Kpna2	2	Kpna2 [nucleoplasm] (R-MMU-9619124) Kpna2 [cytosol] (R-MMU-9619128)	0.655	4
UniProt:Q695T7 SLC6A19	6	SLC6A19 V295Afs57 [plasma membrane] (R-HSA-5659736) SLC6A19 D173N [plasma membrane] (R-HSA-5659723) SLC6A19 I596Hfs73 [plasma membrane] (R-HSA-5659728) SLC6A19 S303L [plasma membrane] (R-HSA-5659746) SLC6A19 R240* [plasma membrane] (R-HSA-5659732) SLC6A19 [plasma membrane] (R-HSA-375483)	0.635	4
UniProt:A0A6M3G9R1 A0A6M3G9R1			0.632	4
UniProt:A0A6G6A1M4 A0A6G6A1M4			0.632	4
UniProt:O14745 NHRF1			0.628	7
UniProt:Q01523-PRO_0000417390 DEFA5			0.623	4
ChEBI:166834 MLN-4760			0.623	9
UniProt:P30990-PRO_0000019524 NTS			0.623	2
UniProt:P01019-PRO_0000032457 AGT			0.623	2
UniProt:P01019-PRO_0000032458 AGT			0.623	5
ChEBI:82721 DALBAVANCIN			0.618	3
UniProt:Q9Y566 SHANK1	1	SHANK1 [cytosol] (R-HSA-6794274)	0.609	2
UniProt:Q96L92 SNX27			0.609	2
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.599	4
UniProt:Q9H2X3 CLC4M			0.591	3
UniProt:A0A6B9WHD3 A0A6B9WHD3			0.589	2
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.57	4
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.557	19
ChEBI:16393 SPHINGOSINE			0.544	4
UniProt:Q5GDB5 Q5GDB5			0.524	2
UniProt:Q14416 GRM2	1	GRM2 [plasma membrane] (R-HSA-420468)	0.524	2
UniProt:P05067-PRO_0000000092 APP			0.489	3
UniProt:O15393 TMPRSS2	2	TMPRSS2 [extracellular region] (R-HSA-9681528) TMPRSS2 [plasma membrane] (R-HSA-9686707)	0.463	3
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128fs3 [cytosol] (R-HSA-3642173) TGFBR2 K128fs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.463	2

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