N-glycan trimming of Spike

Stable Identifier
R-HSA-9683663
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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N-glycan trimming of Spike
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N-glycan side chains on the nascent SARS-CoV-1 spike protein get their terminal glucose moieties cleaved by ER glucosidases I and II, before folding. Iminosugars inhibit this process and are good candidates for broad-spectrum anivirals (Zhao et al, 2015).
Literature References
PubMed ID Title Journal Year
25348530 Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2

Lin, H, Guo, F, Mehta, A, Comunale, MA, Guo, JT, Chang, J, Jain, P, Zhao, X, Cuconati, A, Block, TM, Sehgal, M

Antimicrob. Agents Chemother. 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glucan 1,3-alpha-glucosidase activity of ER alpha-glucosidases [endoplasmic reticulum lumen]

Physical Entity
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
Activity
glucan 1,3-alpha-glucosidase activity (GO:0033919)
This event is regulated
Negatively by
Regulator
ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen] (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-08)
Created
Stephan, R  (2020-04-17)
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