RTC binds SARS-CoV-1 genomic RNA complement (minus strand)

Stable Identifier
R-HSA-9685597
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol, double membrane vesicle viral factory outer membrane
ReviewStatus
5/5
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RTC binds SARS-CoV-1 genomic RNA complement (minus strand)
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After synthesizing the complementary minus RNA of the plus strand viral genomic RNA, SARS-CoV-1 replication-transcription complex (RTC) associates with the minus strand to initiate plus strand synthesis and to initiate transcription of subgenomic (sg) mRNAs (Ahn et al. 2012).
Literature References
PubMed ID Title Journal Year
22791111 Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates

Ahn, DG, Oh, JW, Choi, JK, Taylor, DR

Arch. Virol. 2012
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Output
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as an event of
Orthologous Events
RTC binds SARS-CoV-2 genomic RNA complement (minus strand) (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Orlic-Milacic, M  (2020-04-30)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Orlic-Milacic, M  (2020-04-23)
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