Endocytosis of protein 3a

Stable Identifier
R-HSA-9685950
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
plasma membrane, endocytic vesicle membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Endocytosis of protein 3a
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Protein 3a is rapidly internalized into cells by endocytosis. It contains a Yxxφ motif and also diacidic motifs which are typically found in internalized membrane proteins (Tan et al, 2004). The ability to be internalized is necessary for the protein's pro-apoptotic function (Wong et al, 2006; Chan et al, 2009).
Literature References
PubMed ID Title Journal Year
16212942 In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila

Chui, YL, Chen, Y, Fung, KP, Chan, CM, Chan, PK, Chan, HY, Chan, CS, Tsui, SK, Wong, SL, Waye, MM

Biochem. Biophys. Res. Commun. 2005
19398035 The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function

Zhai, S, Tsoi, H, Tsui, SK, Yao, X, Chan, CM, Wong, CO, Chan, WM, Chan, WY, Chan, HY

Int. J. Biochem. Cell Biol. 2009
15194747 A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis

Tan, TH, Hong, W, Teng, E, Tan, YJ, Fielding, BC, Ooi, EE, Lim, SG, Tan, HC, Shen, S, Goh, PY

J. Virol. 2004
Participants
Input
Output
Participates
as an event of
Orthologous Events
Endocytosis of protein 3a (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-28)
Created
Stephan, R  (2020-04-28)
Cite Us!