Accessory proteins are recruited to the maturing virion

Stable Identifier
R-HSA-9686174
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
ReviewStatus
5/5
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Accessory proteins are recruited to the maturing virion
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In addition to the main structural proteins and the nucleocapsid, the mature virion may also contain low proportions of accessory proteins, including protein 3a and 7a (reviewed in McBride and Fielding, 2012). Protein 3a has been shown to interact with E, M, S and protein 7a and is estimated to be present in the virion at 2/3 the molar ratio of E protein (Ito et al, 2005; Shen et al, 2005; Tan et al, 2004). Although 3a tetramers are predicted to act as ion channels in the host plasma membrane, increasing cell permeability, the role of 3a in the mature virion is not clear (Lu et al, 2006; reviewed in McBride and Fielding, 2012). Protein 7a is type 1 transmembrane protein that interacts with M, E, S and protein 3a and may be incorporated into the mature virion. What functional role protein 7a may play in the assembled virion is unclear (Huang et al, 2006; Fielding et al, 2004; Tan et al, 2004).
Literature References
PubMed ID Title Journal Year
23202509 The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis

McBride, R, Fielding, BC

Viruses 2012
16894145 Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release

Lu, W, Zheng, BJ, Xu, K, Schwarz, W, Du, L, Wong, CK, Chen, J, Duan, S, Deubel, V, Sun, B

Proc. Natl. Acad. Sci. U.S.A. 2006
15807784 Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor

Tohge, T, Nishiyama, Y, Hirai, MY, Yano, M, Nakajima, J, Awazuhara, M, Inoue, E, Takahashi, H, Goodenowe, DB, Kitayama, M, Noji, M, Yamazaki, M, Saito, K

Plant J. 2005
15194747 A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis

Tan, YJ, Teng, E, Shen, S, Tan, TH, Goh, PY, Fielding, BC, Ooi, EE, Tan, HC, Lim, SG, Hong, W

J. Virol. 2004
16840309 Severe acute respiratory syndrome coronavirus 7a accessory protein is a viral structural protein

Huang, C, Ito, N, Tseng, CT, Makino, S

J. Virol. 2006
15781262 The severe acute respiratory syndrome coronavirus 3a is a novel structural protein

Shen, S, Lin, PS, Chao, YC, Zhang, A, Yang, X, Lim, SG, Hong, W, Tan, YJ

Biochem. Biophys. Res. Commun. 2005
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Orthologous Events
Accessory proteins are recruited to the maturing virion (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Cross References
Mondo
Authored
Rothfels, K  (2020-04-22)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Rothfels, K  (2020-04-28)
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