Reactome | p-S365-TERF2 [nucleoplasm]

p-S365-TERF2 [nucleoplasm]

Stable Identifier

R-HSA-9686530

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S365-TRF2

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Extension of Telomeres (Homo sapiens)
      - Telomere Extension By Telomerase (Homo sapiens)
        
        CDK2:CCNA phosphorylates TERF2 (Homo sapiens)
        
        Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
        
        Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
        
        p-S365-TERF2 homodimer [nucleoplasm] (Homo sapiens)
        
        p-S365-TERF2 [nucleoplasm] (Homo sapiens)
        
        PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)
        
        Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
        
        Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
        
        p-S365-TERF2 homodimer [nucleoplasm] (Homo sapiens)
        
        p-S365-TERF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15554 TERF2

Gene Names

TERF2, TRBF2, TRF2

Chain

chain:1-542

Reference Genes

BioGPS Gene:7014 Q155544

COSMIC (genes):TERF2 TERF2

CTD Gene:7014 Q155544

dbSNP Gene:7014 Q155544

ENSEMBL:ENSG00000132604 TERF2

HGNC:11729 Q155544

KEGG:hsa:7014 Q155544

Monarch:7014 Q155544

NCBI Gene:7014 Q155544

OMIM:602027 Q155544

UCSC:Q15554 Q155544

Reference Transcript

RefSeq:NM_005652.4 Q155544

Participates

as a component of

p-S365-TERF2 homodimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TERF2 [nucleoplasm]

Inferred To

Ghost homologue of p-S365-TERF2 [nucleoplasm] (Xenopus tropicalis)

phospho-Terf2 [nucleoplasm] (Mus musculus)

phospho-Terf2 [nucleoplasm] (Rattus norvegicus)

phospho-TERF2 [nucleoplasm] (Bos taurus)

phospho-TERF2 [nucleoplasm] (Canis familiaris)

phospho-TERF2 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 365

Coordinate

365

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_005643.2

OpenTargets

ENSG00000132604

ENSEMBL

ENSP00000254942, ENST00000254942, ENST00000567296, ENSP00000454955, ENSG00000132604

HPA

ENSG00000132604-TERF2

GeneCards

TERF2

PRO

Q15554

Pharos - Targets

Q15554

GlyGen

Q15554

PDB

4RQI, 1H6P, 3BUA, 7C5D, 6J67, 5XYF, 5WQD, 1XG1, 1W0U, 4M7C, 3K6G, 3BU8, 1VF9, 1VFC, 3SJM

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.886	10
UniProt:P54132 BLM	2	BLM [nucleoplasm] (R-HSA-174881) 4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883)	0.691	8
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.681	4
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.655	8
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.602	3
UniProt:Q8NEM0 MCPH1	1	MCPH1 [nucleoplasm] (R-HSA-2429638)	0.582	5
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.544	2
UniProt:Q13415 ORC1	5	ORC1 [nucleoplasm] (R-HSA-68522) ORC1 [cytosol] (R-HSA-113840) p-S,T-ORC1 [nucleoplasm] (R-HSA-68943) PolyUb,p-S,T-ORC1 [nucleoplasm] (R-HSA-9032189) PolyUb,p-S,T-ORC1 [cytosol] (R-HSA-9032195)	0.544	2
UniProt:Q6NZI2 PTRF	2	PTRF [nucleoplasm] (R-HSA-74981) CAVIN1 [plasma membrane] (R-HSA-9714278)	0.527	2
UniProt:P06865 HEXA	3	HEXA(23-73) [lysosomal lumen] (R-HSA-9842401) HEXA(88-528) [lysosomal lumen] (R-HSA-1605799) HEXA Y427Ifs*5 [lysosomal lumen] (R-HSA-3700918)	0.527	2
UniProt:P56559 ARL4C	1	ARL4C [plasma membrane] (R-HSA-9618406)	0.527	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.508	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.508	2
UniProt:Q13472 TOP3A	2	TOP3A [mitochondrial matrix] (R-HSA-9914882) TOP3A [nucleoplasm] (R-HSA-912452)	0.463	4

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