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p-S365-TERF2 [nucleoplasm]
Stable Identifier
R-HSA-9686530
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S365-TRF2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
CDK2:CCNA phosphorylates TERF2 (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
p-S365-TERF2 homodimer [nucleoplasm] (Homo sapiens)
p-S365-TERF2 [nucleoplasm] (Homo sapiens)
PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
p-S365-TERF2 homodimer [nucleoplasm] (Homo sapiens)
p-S365-TERF2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15554 TERF2
Gene Names
TERF2, TRBF2, TRF2
Chain
chain:1-542
Reference Genes
BioGPS Gene:7014 Q155544
COSMIC (genes):TERF2 TERF2
CTD Gene:7014 Q155544
dbSNP Gene:7014 Q155544
ENSEMBL:ENSG00000132604 TERF2
HGNC:11729 Q155544
KEGG:hsa:7014 Q155544
Monarch:7014 Q155544
NCBI Gene:7014 Q155544
OMIM:602027 Q155544
UCSC:Q15554 Q155544
Reference Transcript
RefSeq:NM_005652.4 Q155544
Participates
as a component of
p-S365-TERF2 homodimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
TERF2 [nucleoplasm]
Inferred To
Ghost homologue of p-S365-TERF2 [nucleoplasm]
(Xenopus tropicalis)
phospho-Terf2 [nucleoplasm]
(Mus musculus)
phospho-Terf2 [nucleoplasm]
(Rattus norvegicus)
phospho-TERF2 [nucleoplasm]
(Bos taurus)
phospho-TERF2 [nucleoplasm]
(Canis familiaris)
phospho-TERF2 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 365
Coordinate
365
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_005643.2
OpenTargets
ENSG00000132604
ENSEMBL
ENSP00000254942
,
ENST00000254942
,
ENST00000567296
,
ENSP00000454955
,
ENSG00000132604
HPA
ENSG00000132604-TERF2
GeneCards
TERF2
PRO
Q15554
Pharos - Targets
Q15554
GlyGen
Q15554
PDB
4RQI
,
1H6P
,
3BUA
,
7C5D
,
6J67
,
5XYF
,
5WQD
,
1XG1
,
1W0U
,
4M7C
,
3K6G
,
3BU8
,
1VF9
,
1VFC
,
3SJM
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NUX5 POT1
1
POT1 [nucleoplasm]
(R-HSA-174890)
0.886
10
UniProt:P54132 BLM
2
BLM [nucleoplasm]
(R-HSA-174881)
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
0.691
8
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.681
4
UniProt:Q14191 WRN
2
WRN [nucleoplasm]
(R-HSA-67387)
monoSUMO1-K356,K496,K898-WRN [nucleoplasm]
(R-HSA-4568904)
0.655
8
UniProt:Q13416 ORC2
1
ORC2 [nucleoplasm]
(R-HSA-68405)
0.602
3
UniProt:Q8NEM0 MCPH1
1
MCPH1 [nucleoplasm]
(R-HSA-2429638)
0.582
5
UniProt:Q13315 ATM
5
ATM [cytosol]
(R-HSA-9665171)
ATM [peroxisomal matrix]
(R-HSA-9665169)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [nucleoplasm]
(R-HSA-69484)
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
0.544
2
UniProt:Q13415 ORC1
5
ORC1 [nucleoplasm]
(R-HSA-68522)
ORC1 [cytosol]
(R-HSA-113840)
p-S,T-ORC1 [nucleoplasm]
(R-HSA-68943)
PolyUb,p-S,T-ORC1 [nucleoplasm]
(R-HSA-9032189)
PolyUb,p-S,T-ORC1 [cytosol]
(R-HSA-9032195)
0.544
2
UniProt:Q6NZI2 PTRF
2
PTRF [nucleoplasm]
(R-HSA-74981)
CAVIN1 [plasma membrane]
(R-HSA-9714278)
0.527
2
UniProt:P06865 HEXA
3
HEXA(23-73) [lysosomal lumen]
(R-HSA-9842401)
HEXA(88-528) [lysosomal lumen]
(R-HSA-1605799)
HEXA Y427Ifs*5 [lysosomal lumen]
(R-HSA-3700918)
0.527
2
UniProt:P56559 ARL4C
1
ARL4C [plasma membrane]
(R-HSA-9618406)
0.527
2
UniProt:Q86VM9 ZC3H18
1
ZC3H18 [nucleoplasm]
(R-HSA-9930040)
0.508
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.508
2
UniProt:Q13472 TOP3A
2
TOP3A [mitochondrial matrix]
(R-HSA-9914882)
TOP3A [nucleoplasm]
(R-HSA-912452)
0.463
4
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