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p-S365-TERF2 [nucleoplasm]
Stable Identifier
R-HSA-9686530
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S365-TRF2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
CDK2:CCNA phosphorylates TERF2 (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
p-S365-TERF2 homodimer [nucleoplasm] (Homo sapiens)
p-S365-TERF2 [nucleoplasm] (Homo sapiens)
PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
p-S365-TERF2 homodimer [nucleoplasm] (Homo sapiens)
p-S365-TERF2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15554 TERF2
Gene Names
TERF2, TRBF2, TRF2
Chain
chain:1-542
Reference Genes
BioGPS Gene:7014 TERF2
COSMIC (genes):TERF2 TERF2
CTD Gene:7014 TERF2
dbSNP Gene:7014 TERF2
ENSEMBL:ENSG00000132604 TERF2
HGNC:11729 TERF2
KEGG Gene (Homo sapiens):7014 TERF2
Monarch:7014 TERF2
NCBI Gene:7014 TERF2
OMIM:602027 TERF2
UCSC:Q15554 TERF2
Reference Transcript
RefSeq:NM_005652.4 TERF2
Other Identifiers
0002190450
11730306_at
11761640_x_at
1299_at
1555183_at
1555185_x_at
16827662
203611_at
3696572
3696573
3696574
3696576
3696580
3696581
3696582
3696583
3696584
3696585
3696589
3696590
3696592
3696593
3696594
3696595
41097_at
7014
8002289
A_23_P417200
GE54052
GO:0000228
GO:0000723
GO:0000781
GO:0000783
GO:0000784
GO:0001673
GO:0001701
GO:0003674
GO:0003677
GO:0003691
GO:0003720
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006259
GO:0006278
GO:0006810
GO:0006950
GO:0007049
GO:0007568
GO:0008022
GO:0008089
GO:0008150
GO:0009058
GO:0009790
GO:0010628
GO:0010629
GO:0015031
GO:0016233
GO:0016604
GO:0016779
GO:0019899
GO:0022607
GO:0030705
GO:0030870
GO:0031627
GO:0031848
GO:0032204
GO:0032205
GO:0032206
GO:0032208
GO:0032210
GO:0032211
GO:0032214
GO:0032991
GO:0034641
GO:0042162
GO:0042592
GO:0042803
GO:0043226
GO:0044877
GO:0048856
GO:0051000
GO:0051276
GO:0061820
GO:0070187
GO:0070198
GO:0090398
GO:0098505
GO:0099087
GO:1903770
GO:1903824
GO:1904115
GO:1904354
GO:1904357
GO:1904430
GO:1905778
GO:1905839
GO:2000773
HMNXSV003050262
Hs2.100030.2.S1_3p_at
ILMN_1768488
PH_hs_0022164
TC16001222.hg
X93512_at
g5032168_3p_at
Participates
as a component of
p-S365-TERF2 homodimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
TERF2 [nucleoplasm]
Inferred To
phospho-Terf2 [nucleoplasm]
(Mus musculus)
phospho-Terf2 [nucleoplasm]
(Rattus norvegicus)
phospho-TERF2 [nucleoplasm]
(Canis familiaris)
phospho-TERF2 [nucleoplasm]
(Sus scrofa)
phospho-terfa [nucleoplasm]
(Danio rerio)
Modified Residues
Name
O-phospho-L-serine at 365
Coordinate
365
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_005643.2
OpenTargets
ENSG00000132604
GeneCards
Q15554
HPA
ENSG00000132604-TERF2
Ensembl
ENSP00000254942
,
ENSG00000132604
,
ENST00000254942
,
ENSP00000454955
,
ENST00000567296
PRO
Q15554
PDB
5XYF
,
5WQD
,
4M7C
,
4RQI
,
3SJM
,
3K6G
,
3BUA
,
1W0U
,
1VF9
,
7C5D
,
1H6P
,
1VFC
,
1XG1
,
6J67
,
3BU8
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NUX5 POT1
1
POT1 [nucleoplasm]
(R-HSA-174890)
0.802
7
UniProt:P54132 BLM
2
BLM [nucleoplasm]
(R-HSA-174881)
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
0.691
8
UniProt:Q14191 WRN
2
WRN [nucleoplasm]
(R-HSA-67387)
SUMO1-K356,K496,K898-WRN [nucleoplasm]
(R-HSA-4568904)
0.655
8
UniProt:Q8NEM0 MCPH1
1
MCPH1 [nucleoplasm]
(R-HSA-2429638)
0.582
5
UniProt:Q13315 ATM
5
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
ATM [nucleoplasm]
(R-HSA-69484)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [peroxisomal matrix]
(R-HSA-9665169)
ATM [cytosol]
(R-HSA-9665171)
0.544
2
UniProt:Q13415 ORC1
4
PolyUb,p-S,T-ORC1 [nucleoplasm]
(R-HSA-9032189)
ORC1 [nucleoplasm]
(R-HSA-68522)
PolyUb,p-S,T-ORC1 [cytosol]
(R-HSA-9032195)
p-S,T-ORC1 [nucleoplasm]
(R-HSA-68943)
0.544
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.508
2
UniProt:Q13472 TOP3A
1
TOP3A [nucleoplasm]
(R-HSA-912452)
0.463
4
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