Reactome | TMPRSS2 [plasma membrane]

TMPRSS2 [plasma membrane]

Stable Identifier

R-HSA-9686707

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Transmembrane protease serine 2 ecNumber3.4.21.-/ecNumber, TMPS2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9BYF1

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External Reference Information

External Reference

UniProt:O15393 TMPRSS2

Gene Names

TMPRSS2, PRSS10

Chain

chain:1-255, chain:256-492

Reference Genes

BioGPS Gene:7113 TMPRSS2

COSMIC (genes):TMPRSS2 TMPRSS2

CTD Gene:7113 TMPRSS2

dbSNP Gene:7113 TMPRSS2

ENSEMBL:ENSG00000184012 TMPRSS2

ENSEMBL_homo_sapiens_GENE:ENSG00000184012.14 TMPRSS2

HGNC:11876 TMPRSS2

KEGG Gene (Homo sapiens):7113 TMPRSS2

Monarch:7113 TMPRSS2

NCBI Gene:7113 TMPRSS2

OMIM:602060 TMPRSS2

UCSC:O15393 TMPRSS2

Reference Transcript

Other Identifiers

11724909_a_at

11724910_a_at

11724911_a_at

124905021

16925872

205102_PM_at

205102_at

211689_PM_s_at

211689_s_at

226553_PM_at

226553_at

34996_at

3933040

3933041

3933042

3933045

3933047

3933052

3933053

3933056

3933057

3933060

3933061

3933062

3933071

3933072

3933074

3933075

3933078

3933090

3933091

3933092

3933093

3933094

3933099

3933100

3933101

63329_at

7113

8070467

A_23_P29067

GE59396

GO:0003824

GO:0004252

GO:0005044

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005886

GO:0006508

GO:0008233

GO:0008236

GO:0016020

GO:0016540

GO:0016787

GO:0019081

GO:0038024

GO:0043226

GO:0046598

GO:0051604

GO:0070062

GO:0140096

HMNXSV003007448

HMNXSV003009429

Hs.105807.0.A1_3p_at

ILMN_1791123

PH_hs_0025738

TC21000471.hg

g13540003_3p_s_at

g5032184_3p_at

Participates

as an input of

TMPRSS2 binds TMPRSS2 inhibitors (Homo sapiens)

Other forms of this molecule

TMPRSS2 [extracellular region]

Cross References

RefSeq

XP_011528033.1, NP_001128571.1, NP_005647.3

Guide to Pharmacology - Targets

2421

OpenTargets

ENSG00000184012

ZINC - Substances

TMPS2_HUMAN

ZINC target

O15393

PRO

O15393

PDB

7MEQ

IntEnz

3.4.21.122

HPA

ENSG00000184012-TMPRSS2

GeneCards

O15393

Ensembl

ENSP00000330330, ENSP00000504705, ENSP00000381588, ENSP00000389006, ENSP00000502928, ENSG00000184012, ENST00000332149, ENST00000676973, ENST00000454499, ENSP00000503556, ENST00000398585, ENST00000458356, ENST00000678348, ENST00000679054, ENSP00000391216

Pharos - Targets

O15393

ZINC - Predictions - Purchasable

TMPS2_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01009 SERPINA1	8	SERPINA1 [platelet alpha granule lumen] (R-HSA-141755) SERPINA1 [extracellular region] (R-HSA-141757) SERPINA1 [ficolin-1-rich granule lumen] (R-HSA-6804783) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689734) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [COPII-coated ER to Golgi transport vesicle] (R-HSA-5689731) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (R-HSA-5689435) p-SERPINA1 [endoplasmic reticulum lumen] (R-HSA-8957062) SERPINA1 [endoplasmic reticulum lumen] (R-HSA-8956709)	0.558	2
UniProt:Q9BYF1 ACE2	5	ACE2(18-805) [plasma membrane] (R-HSA-2022344) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480)	0.463	3

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