APC/C:Cdh1 polyubiquitinates SKP2

Stable Identifier
R-HSA-9686969
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RB1-dependent polyubiquitination of SKP2 by the APC/C:Cdh1 complex is an important mechanism of RB1-mediated cell cycle exit, which contributes to the RB1 tumor suppressive role. ABC/C:Cdh1-mediated polyubiquitination targets SKP2 for proteasome-mediated degradation. RB1 and APC/C:Cdh1-dependent degradation of SKP2 allows accumulation of CDKN1B (p27Kip1) in the cell, as CDKN1B is a target of the SKP2-containing SCF ubiquitin ligase complex. CDKN1B acts as a CDK inhibitor, enabling mitotic exit (Ji et al. 2004, Binne et al. 2007).

Literature References
PubMed ID Title Journal Year
17187060 Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit

Binné, UK, Classon, MK, Dick, FA, Wei, W, Rape, M, Kaelin, WG, Näär, AM, Dyson, NJ

Nat. Cell Biol. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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