Expression of SRY in testis differentiation

Stable Identifier
R-HSA-9692241
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the gonadal ridge (genital ridge), the SRY gene is transcribed to yield mRNA and the mRNA is translated to yield SRY protein (De Santa Barbara et al. 2001, Hossain end Saunders 2001, Miyamoto et al. 2008, also inferred from mouse homologs). Transcription of SRY is activated by WT1 (Hossain and Saunders 2001, Miyamoto et al. 2008), GATA4:ZFPM2 (also called GATA4:FOG2) (Miyamoto et al. 2008), and NR5A1 (also called SF1) (De Santa Barbara et al. 2001).

Literature References
PubMed ID Title Journal Year
11207191 Steroidogenic factor-1 contributes to the cyclic-adenosine monophosphate down-regulation of human SRY gene expression

De Santa Barbara, P, Méjean, C, Moniot, B, Malclès, MH, Berta, P, Boizet-Bonhoure, B

Biol. Reprod. 2001
18445271 A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation

Miyamoto, Y, Taniguchi, H, Hamel, F, Silversides, DW, Viger, RS

BMC Mol. Biol. 2008
11278460 The human sex-determining gene SRY is a direct target of WT1

Hossain, A, Saunders, GF

J. Biol. Chem. 2001
Participants
Participates
This event is regulated
Inferred From
Authored
Reviewed
Created
Cite Us!