Reactome | CDC42 binds effectors at the ER membrane

CDC42 binds effectors at the ER membrane

Stable Identifier

R-HSA-9692809

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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CDC42 binds effectors at the ER membrane

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Activated GTP-bound CDC42 binds to kinectin (KTN1) at the endoplasmic reticulum membrane (Hotta et al. 1996).

Active CDC42 also binds the following candidate effectors at the endoplasmic reticulum membrane identified in the screen by Bagci et al. 2020:
LBR (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP	Nat. Cell Biol.	2020
8769096	Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor Mino, A, Kohno, H, Hotta, K, Takai, Y, Tanaka, K	Biochem. Biophys. Res. Commun.	1996