SARS-CoV-1-host interactions

Stable Identifier
R-HSA-9692914
Type
Pathway
Species
Homo sapiens
Related Species
Human SARS coronavirus
ReviewStatus
5/5
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Coronaviruses are a group of enveloped viruses with single‑stranded, positive‑sense RNA genomes. Each of the steps of viral replication - attachment and entry, translation of viral replicase, genome transcription and replication, translation of structural proteins, and virion assembly and release - involves host factors. These interactions can cause alterations in cellular structure and physiology, and activate host stress responses, autophagy, cell death, and processes of innate immunity (Fung TS & Liu DX 2019). This Reactome module describes molecular mechanisms by which severe acute respiratory syndrome coronavirus type 1 (SARS-CoV-1) modulates host cell death pathways, innate immune responses, translation, intracellular signaling and regulatory pathways, and PDZ-mediated cell-cell junctions.
Literature References
PubMed ID Title Journal Year
33060197 Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Dunham, I, Kehrer, T, Southworth, DR, Alessi, DR, García-Sastre, A, Jura, N, Park, J, Liu, X, Frost, A, Li, Y, Kochs, G, Davies, P, Shokat, KM, Smith, AM, Foussard, H, Beltrao, P, Liu, Y, Koh, C, Vignuzzi, M, Tsui, TKM, Pollard, KS, Williams, DM, Merz, GE, Bouhaddou, M, Faust, B, Vallejo-Gracia, A, Tummino, TA, Li, F, Logue, J, Hemphill, KR, Guo, JZ, Barrio-Hernandez, I, Verba, KA, Shoichet, B, Pospiech, TH, Paulino, J, Ideker, T, Tse, E, Deshpande, I, Chio, CM, Fabius, JM, Geyer, A, Obernier, K, Safari, M, Pourmal, S, Simoneau, CR, Haas, P, Moreno, E, Zhang, Z, Cakir, M, Soucheray, M, Hüttenhain, R, Hiatt, J, Ott, M, Klesh, RJ, Rihn, S, Kortemme, T, Moritz, M, Burness, KA, Kaake, RM, Zhao, J, Carlson-Stevermer, J, Weston, S, Memon, D, Gordon, DE, Reid, E, Roth, TL, Shi, Y, Peden, AA, Azumaya, CM, Trenker, R, Weckstein, AR, Manglik, A, Vallet, T, Fraser, JS, Xu, J, White, KM, Braberg, H, Modak, M, Rathore, U, Batra, J, Wang, F, Hastie, CJ, Grosse, R, Toth, R, Zhang, Y, Li, YL, Goodman, N, Patel, AH, Basler, CF, Whitis, N, Keough, KC, QCRG Structural Biology Consortium, -, Elliott, M, Maures, T, Oki, J, Kim, K, Nowotny, C, Asarnow, D, Chazal, M, Gupta, M, Rassen, JA, McGregor, M, Ummadi, M, Khalid, MM, Flores, S, Frieman, MB, Baillie, C, Moss, FR, Weigang, S, Nguyen, HC, Biel, J, Doan, L, Brown, F, Silvas, JA, Palmarini, M, Chen, J, Saltzberg, D, Rojc, A, Pawar, KI, Giesel, DM, Dorward, M, Sangwan, S, Schulze-Gahmen, U, Ulferts, S, McGrath, M, Shun-Shion, AS, Holden, K, Sali, A, Thomas, PV, Kratochvil, HT, Johnson, C, Cakir, Z, Young, ID, Titus, EW, Schaefer, K, Haupt, R, Wilkinson, SG, Puchades, C, Agard, DA, Marrero, MC, Zoonomia Consortium, -, Peters, JK, Dunham, A, Lopez, KE, Nguyen, P, Bowen, A, Rizo, AN, Burke, D, Zhou, F, Naing, ZZC, Hoppe, N, Brilot, AF, Sun, M, Diwanji, D, Fozouni, P, Rosales, R, Rosenberg, OS, Cheng, Y, Abate, C, Diallo, A, Kuchenov, D, Raggett, S, Karim, MA, Thwin, AC, Berardi, F, Ghoussaini, M, Zhang, K, Stroud, RM, Yu, Z, Eckhardt, M, Braxton, JR, Leech, H, Pulido, EH, Chio, US, O'Meara, MJ, Melo, AA, Miorin, L, Owens, TW, Swaney, DL, Wu, D, Petsalaki, E, Lind, AL, Tutuncuoglu, B, Hodder, AJ, Li, J, Rezelj, VV, Haas, KM, Zhou, Y, Lo, M, Jang, G, Jureka, AS, Billesbølle, C, Krogan, NJ, Jin, M, Dickinson, MS, Jouvenet, N, Herrera, N, Campbell, MG, Lam, VL

Science 2020
31226023 Human Coronavirus: Host-Pathogen Interaction

Fung, TS, Liu, DX

Annu. Rev. Microbiol. 2019
Participants
Participates
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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