RHOD binds effectors at the mitochondrial outer membrane

Stable Identifier
Reaction [binding]
Homo sapiens
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Active GTP-bound RHOD binds PAK5 and recruits it to the mitochondrial outer membrane (Wu and Frost 2006).

GTP-bound RHOD also binds HINT2 at the mitochondrial outer membrane, which triggers mitochondrial Ca2+ influx (Chen et al. 2017, supported by Bagci et al. 2020).

VRK2, which can localize to the mitochondrial outer membrane was reported to bind active RHOD by Bagci et al. 2020 and is annotated as a candidate effector.
Literature References
PubMed ID Title Journal Year
28947137 HINT2 triggers mitochondrial Ca2+ influx by regulating the mitochondrial Ca2+ uniporter (MCU) complex and enhances gemcitabine apoptotic effect in pancreatic cancer

Hu, Z, Chen, L, Wang, W, Yang, Q, Xie, H, Zhou, D, Zhang, L, Yao, H, Zhou, L, Song, W, Zheng, S, Ju, B, Sun, Q

Cancer Lett 2017
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP

Nat. Cell Biol. 2020
17064668 Multiple Rho proteins regulate the subcellular targeting of PAK5

Frost, JA, Wu, X

Biochem. Biophys. Res. Commun. 2006
Orthologous Events
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