mRNA1 is translated to pp1ab

Stable Identifier
R-HSA-9694274
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

In about 15% of translation attempts of the genomic viral mRNA1 in the host cell cytosol, a -1 frameshift happens after the nsp10 gene that leads to translation of the full pp1ab polyprotein (Baranov et al, 2005).
Literature References
PubMed ID Title Journal Year
15680415 Programmed ribosomal frameshifting in decoding the SARS-CoV genome

Baranov, PV, Atkins, JF, Henderson, CM, Howard, MT, Gesteland, RF, Anderson, CB

Virology 2005
Participants
Participates
Inferred From
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
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