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3a is externalized together with membrane structures
Stable Identifier
R-HSA-9694308
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of protein 3a (Homo sapiens)
3a is externalized together with membrane structures (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
Membranous structures containing protein 3a are shed from the cell membrane (Huang et al, 2006)
Literature References
PubMed ID
Title
Journal
Year
16352545
Severe acute respiratory syndrome coronavirus 3a protein is released in membranous structures from 3a protein-expressing cells and infected cells
Huang, C
,
Makino, S
,
Peters, CJ
,
Ito, N
,
Narayanan, K
J. Virol.
2006
Participants
Input
Host Derived Lipid Bilayer Membrane [plasma membrane]
O-glycosyl 3a tetramer [plasma membrane]
(Severe acute respiratory syndrome coronavirus 2)
Output
3a:membranous structure [extracellular region]
(Severe acute respiratory syndrome coronavirus 2)
Participates
as an event of
Maturation of protein 3a (Homo sapiens)
Inferred From
3a is externalized together with membrane structures (Homo sapiens)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R (2020-08-28)
Reviewed
Acencio, ML (2020-09-09)
Created
Cook, J (2020-07-07)
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